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Bergen Open Research Archive

Browsing by Author "Bjerkvig, Rolf"

Bergen Open Research Archive

Browsing by Author "Bjerkvig, Rolf"

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  • Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Journal article, Springer, 2015-01)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
  • Najbauer, Joseph; Huszthy, Peter Csaba; Barish, Michael E.; Garcia, Elizabeth; Metz, Marianne Z.; Myers, Sarah M.; Gutova, Margarita; Frank, Richard T.; Miletic, Hrvoje; Kendall, Stephen E.; Glackin, Carlotta A.; Bjerkvig, Rolf; Aboody, Karen S. (Peer reviewed; Journal article, Public Library of Science, 2012-04-23)
    Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the ...
  • Svendsen, Agnete; Verhoeff, Joost J. C.; Immervoll, Heike; Brøgger, Jan C.; Kmiecik, Justyna; Poli, Aurélie; Netland, Inger A.; Planagumà, Jesús; Torsvik, Anja; Sakariassen, Per Øystein; Bjerkvig, Rolf; Enger, Per Øyvind; Tronstad, Karl Johan (Peer reviewed; Journal article, Springer, 2011-08-24)
    Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ...
  • Stieber, Daniel; Golebiewska, Anna; Evers, Lisa; Lenkiewicz, Elizabeth; Brons, Nicolas H.C.; Nicot, Nathalie; Oudin, Anaïs; Bougnaud, Sébastien; Hertel, Frank; Bjerkvig, Rolf; Vallar, Laurent; Barrett, Michael T.; Niclou, Simone P. (Journal article, Springer, 2014-02)
    Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ...
  • Raa, Anette; Stansberg, Christine; Steen, Vidar Martin; Bjerkvig, Rolf; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Journal article, BioMed Central, 2007-01-30)
    This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Methods: One group of animals was exposed to ...
  • Wiig, Helge; Tenstad, Olav; Iversen, Per Ole; Kalluri, Raghu; Bjerkvig, Rolf (Journal article; Peer reviewed, BioMed Central, 2010-07-23)
    Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on ...
  • Daphu, Inderjit Kaur; Horn, Sindre August; Stieber, Daniel; Varughese, Jobin K.; Spriet, Endy; Dale, Hege Avsnes; Skaftnesmo, Kai Ove; Bjerkvig, Rolf; Thorsen, Frits Alan (Journal article, MDPI, 2014-05-16)
    Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAFV600E mutation, which activates the mitogen-activated protein kinase ...
  • Keunen, Olivier; Taxt, Torfinn; Grüner, Renate; Lund-Johansen, Morten; Tonn, Joerg-Christian; Pavlin, Tina; Bjerkvig, Rolf; Niclou, Simone P.; Thorsen, Frits Alan (Journal article, Elsevier, 2014-09-30)
    The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology remains ...
  • Wang, Jian; Miletic, Hrvoje; Sakariassen, Per Øystein; Huszthy, Peter Csaba; Jacobsen, Hege; Brekkå, Narve; Li, Xingang; Zhao, Peng; Mørk, Sverre; Chekenya, Martha; Bjerkvig, Rolf; Enger, Per Øyvind (Journal article, BioMed Central, 2009-12-29)
    Background: Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient ...
  • Jul-Larsen, Åsne; Grudic, Amra; Bjerkvig, Rolf; Bøe, Stig O. (Peer reviewed; Journal article, BioMed Central, 2010-11-21)
    Background The promyelocytic leukemia (PML) protein participates in a number of cellular processes, including transcription regulation, apoptosis, differentiation, virus defense and genome maintenance. This protein is ...
  • Wang, Jian; Svendsen, Agnete; Kmiecik, Justyna; Immervoll, Heike; Skaftnesmo, Kai Ove; Planagumà, Jesús; Reed, Rolf K.; Bjerkvig, Rolf; Miletic, Hrvoje; Enger, Per Øyvind; Rygh, Cecilie Brekke; Chekenya, Martha (Peer reviewed; Journal article, PLoS Computational Biology, 2011-07-29)
    Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including ...

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