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Bergen Open Research Archive

Browsing by Author "Mitternacht, Simon"

Bergen Open Research Archive

Browsing by Author "Mitternacht, Simon"

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  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-09-15)
    Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-12-08)
    Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Journal article; Peer reviewed, Oxford University Press, 2011)
    An important aspect of understanding protein allostery, and of artificial effector design, is the characterization and prediction of substrate- and effector-binding sites. To find binding sites in allosteric enzymes, many ...
  • Jónsson, Sigurður Ægir; Mitternacht, Simon; Irbäck, Anders (Journal article; Peer reviewed, Elsevier, 2013-06-18)
    Single-molecule pulling experiments on unstructured proteins linked to neurodegenerative diseases have measured rupture forces comparable to those for stable folded proteins. To investigate the structural mechanisms of ...
  • Mitternacht, Simon; Staneva, Iskra; Härd, Torleif; Irbäck, Anders (Journal article; Peer reviewed, Elsevier, 2011)
    Small soluble oligomers, and dimers in particular, of the amyloid β-peptide (Aβ) are believed to play an important pathological role in Alzheimer's disease. Here, we investigate the spontaneous dimerization of Aβ42, with ...

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