Browsing by Author "Schwede, Frank"
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Nature Publishing Group, 2013)We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ...
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3 Herfindal, Lars; Krakstad, Camilla; Myhren, Lene Elisabeth; Hagland, Hanne; Kopperud, Reidun Kristin; Teigen, Knut; Schwede, Frank; Kleppe, Rune; Døskeland, Stein Ove (PLoS, 2014-04-16)Analogs of the cyclic nucleotides cAMP and cGMP have been extensively used to mimic or modulate cellular events mediated by protein kinase A (PKA), Exchange protein directly activated by cAMP (Epac), or protein kinase G ...
Specificity of commonly used cyclic nucleotides with PKA, PKG and Epac-implementing microcalorimetry to determine PDE activities Beavo, Joseph A.; Bos, Johannes L.; Butt, Elke; Døskeland, Stein Ove; Genieser, Hans-Gottfried; Hinds, Thomas R.; Poppe, Heiko; Rehmann, Holger; Rybalkin, Sergei D.; Schwede, Frank; Tang, Xiao-Bo (BioMed Central, 2007-07-25)