Now showing items 1-14 of 14

  • The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine 

    Løland, Kjetil Halvorsen; Bleie, Øyvind; Borgeraas, Heidi; Strand, Elin; Ueland, Per Magne; Svardal, Asbjørn; Nordrehaug, Jan Erik; Nygård, Ottar (Public Library of Science, 2013-05-29)
    Objective: We previously showed that treatment with folic acid (FA)/B12 was associated with more rapid progression of coronary artery disease (CAD). High doses of FA may induce methylation by increasing the availability ...
    Journal article
  • Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-Vitamin supplementation 

    Holm, Pål Ivar; Bleie, Øyvind; Ueland, Per Magne; Lien, Ernst Asbjørn; Refsum, Helga; Nordrehaug, Jan Erik; Nygård, Ottar (2004)
    Objective—Betaine is a substrate in the betaine– homocysteine methyltransferase reaction, converting homocysteine to methionine. There are only sparse data on plasma betaine as a determinant of the plasma total homocysteine ...
    Journal articlePeer reviewed
  • Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes 

    Stone, Nicole; Pangilinan, Faith; Molloy, Anne M.; Shane, Barry; Scott, John M.; Ueland, Per Magne; Mills, James L.; Kirke, Peader N.; Sethupathy, Praveen; Brody, Lawrence C. (Public Library of Science, 2011-07-12)
    One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and ...
    Peer reviewedJournal article
  • Dietary predictors of plasma total homocysteine concentration in the Hordaland Homocysteine Study 

    Konstantinova, Svetlana V.; Vollset, Stein Emil; Berstad, Paula; Ueland, Per Magne; Drevon, Christian A.; Refsum, Helga; Tell, Grethe Seppola (Cambridge University Press, 2007)
    Established dietary predictors of plasma total homocysteine (tHcy) include folate, riboflavin, and vitamins B6 and B12, while information is scarce regarding other dietary components. The aim of this study was to examine ...
    Journal articlePeer reviewed
  • Effect of Folic Acid Supplementation on Levels of Circulating Monocyte Chemoattractant Protein-1 and the Presence of Intravascular Ultrasound Derived Virtual Histology Thin-Cap Fibroatheromas in Patients with Stable Angina Pectoris 

    Løland, Kjetil Halvorsen; Bleie, Øyvind; Strand, Elin; Ueland, Per Magne; Nordrehaug, Jan Erik; Garcia-Garcia, Hector M.; Serruys, Patrick W.; Nygård, Ottar (Public Library of Science, 2013-07-25)
    Background: Virtual Histology Intravascular Ultrasound (VH–IVUS) may be used to detect early signs of unstable coronary artery disease. Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis ...
    Journal article
  • Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: A prospective cohort study 

    Rebnord, Eirik Wilberg; Pedersen, Eva Kristine Ringdal; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Meyer, Klaus; Schartum-Hansen, Hall; Løland, Kjetil Halvorsen; Seifert, Reinhard; Ueland, Per Magne; Nilsen, Dennis W. T.; Nordrehaug, Jan Erik; Nygård, Ottar (Elsevier, 2015-05)
    Objective: Associations of glycated hemoglobin A1c (HbA1c) levels to incident coronary and cardiovascular events among non-diabetic patients with coronary artery disease are unclear. We investigated relations of HbA1c ...
    Journal article
  • Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study 

    Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Midttun, Øyvind; Ulvik, Arve; Eide, Geir Egil; Meyer, Klaus; Tell, Grethe Seppola (WileyBritish Society for Immunology, 2014-04-24)
    The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase ...
    Journal article
  • Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: The Hordaland Health Study 

    Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Øyen, Jannike; Meyer, Klaus; Midttun, Øivind; Eide, Geir Egil; Tell, Grethe Seppola (Springer, 2014-05-10)
    Summary The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip ...
    Journal article
  • Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study 

    Zuo, Hui; Tell, Grethe Seppola; Vollset, Stein Emil; Ueland, Per Magne; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve; Eussen, Simone (Wiley, 2014-06-19)
    Background It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and ...
    Journal article
  • Markers of vitamin B6 status and metabolism as predictors of incident cancer: The Hordaland Health Study. 

    Zuo, Hui; Ueland, Per Magne; Eussen, Simone; Tell, Grethe Seppola; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Wiley, 2014-11-26)
    Dietary intake and/or circulating concentrations of vitamin B6 have been associated with risk of cancer, but results are inconsistent and mechanisms uncertain. Pyridoxal 5'-phosphate (PLP) is the most commonly used marker ...
    Journal article
  • Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers 

    Gloyn, Anna L.; Faber, Johan H.; Malmodin, Daniel; Thanabalasingham, Gaya; Lam, Francis; Ueland, Per Magne (Public Library of Science, 2012-07-30)
    It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ...
    Peer reviewedJournal article
  • Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

    Nitter, Mathilde Hjelle; Norgård, Benedicte Wentzel; De Vogel, Stefan; Eussen, Simone; Meyer, Klaus; Ulvik, Arve; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Bjørge, Tone; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Racine, Antoine; Cottet, Vanessa; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Bamia, Christina; Naska, Androniki; Grioni, Sara; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Van Kranen, Henk J.; Peeters, Petra H. M.; Weiderpass, Elisabete; Dorronsoro, Miren; Jakszyn, Paula; Sánchez, María-José; Argüelles, Marcial Vicente; Huerta, José-Maria; Barricarte, Aurelio; Johansson, Matthias; Ljuslinder, Ingrid; Khaw, Kay Tee; Wareham, Nicholas J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Gunter, Mark J.; Riboli, Élio B. (Oxford University Press, 2014-08)
    Background Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as ...
    Journal article
  • Prognostic impact of vitamin B6 metabolism in lung cancer 

    Galluzzi, Lorenzo; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken André; Pinna, Guillaume; Eisenberg, Tobias; Goubar, Aïcha; Martins, Isabelle; Michels, Judith; Kratassiouk, Guerorgui; Carmona-Gutierrez, Didac; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frederic; Kepp, Oliver; Shen, Sheshi; Tailler, Maximilien; Niso-Santano, Mireia; Morselli, Eugenia; Criollo, Alfredo; Adjemian, Sandy; Jemaa, Mohamed; Chaba, Kariman; Pailleret, Claire; Michaud, Mickaël; Pietrocola, Federico; Tajeddine, Nicolas; Rouge, Thibault de La Motte; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angélique; Dorvault, Nicolas; Girard, Philippe; Gouy, Sébastien; Pautier, Patricia; Jägemann, Nora; Nickel, Ann-Christin; Marsili, Sabrina; Paccard, Caroline; Servant, Nicolas; Hupé, Philippe; Behrens, Carmen; Behnam-Motlagh, Paviz; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Øivind; Ueland, Per Magne; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienne; Castedo, Maria; Madeo, Frank; Barillot, Emmanuel; Thomale, Jürgen; Wistuba, Ignacio Ivan; Sautes-Fridman, Catherine; Zitvogel, Laurence; Soria, Jean-Charles; Harel-Bellan, Annick; Kroemer, Guido (Elsevier, 2012-08-30)
    Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ...
    Journal article
  • Smoking and body fat mass in relation to bone mineral density and hip fracture: The Hordaland Health Study 

    Øyen, Jannike; Gjesdal, Clara Gram; Nygård, Ottar; Lie, Stein Atle; Meyer, Haakon; Apalset, Ellen M.; Ueland, Per Magne; Pedersen, Eva Kristine Ringdal; Midttun, Øivind; Vollset, Stein Emil; Tell, Grethe Seppola (PLoS, 2014-03-25)
    Lower bone mineral density (BMD) in smokers may be attributable to lower body weight or fat mass, rather than to a direct effect of smoking. We analyzed the effects of smoking exposure, assessed by plasma cotinine, and ...
    Journal article