BORA - UiB

Bergen Open Research Archive

Browsing Department of Informatics by Author "Berezovsky, Igor N."

Bergen Open Research Archive

Browsing Department of Informatics by Author "Berezovsky, Igor N."

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  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-09-15)
    Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-12-08)
    Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are ...
  • Goncearenco, Alexander; Berezovsky, Igor N. (Journal article, BioMed Central, 2012-05-30)
    Background: Despite recent progress in studies of the evolution of protein function, the questions what were the first functional protein domains and what were their basic building blocks remain unresolved. Previously, ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Journal article; Peer reviewed, Oxford University Press, 2011)
    An important aspect of understanding protein allostery, and of artificial effector design, is the characterization and prediction of substrate- and effector-binding sites. To find binding sites in allosteric enzymes, many ...

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