BORA - UiB

Bergen Open Research Archive

Browsing Department of Informatics by Subject "allosteric regulation"

Bergen Open Research Archive

Browsing Department of Informatics by Subject "allosteric regulation"

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  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-09-15)
    Allosteric regulation involves conformational transitions or fluctuations between a few closely related states, caused by the binding of effector molecules. We introduce a quantity called binding leverage that measures ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Peer reviewed; Journal article, Public Library of Science, 2011-12-08)
    Conformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are ...
  • Mitternacht, Simon; Berezovsky, Igor N. (Journal article; Peer reviewed, Oxford University Press, 2011)
    An important aspect of understanding protein allostery, and of artificial effector design, is the characterization and prediction of substrate- and effector-binding sites. To find binding sites in allosteric enzymes, many ...

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