Now showing items 1-10 of 62
Modelling and expression of the extracellular domain of the human guanylyl cyclase C receptor
(The University of Bergen, 2011-09-14)
The human guanylyl cyclase C receptor is the target for the heat-stable entero- toxin (STa) from enterotoxigenic Escherichia coli, which is responsible for more than 200 million episodes of diarrhea and 300,000 deaths ...
Homeodomain transcription factors Six3 and Six6 have distinct protein binding characteristics
(The University of Bergen, 2015-02-20)
<p>The goal of this study was to characterize Six3 and Six6 proteins interactions and to better understand their functions.</p> <p>The Six class proteins are found in a wide variety of animals ranging from primitive ...
CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
(Public Library of Science, 2008-08-26)
Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ...
Carbohydrate metabolism during vertebrate appendage regeneration: What is its role? How is it regulated? A postulation that regenerating vertebrate appendages facilitate glycolytic and pentose phosphate pathways to fuel macromolecule biosynthesis
We recently examined gene expression during Xenopus tadpole tail appendage regeneration and found that carbohydrate regulatory genes were dramatically altered during the regeneration process. In this essay, we speculate ...
The protein N-alpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells
(BioMed Central, 2009-03-02)
<p>Background: The hNaa10p (hArd1) protein is the catalytic subunit of the human NatA Nα- terminal acetyltransferase complex. The NatA complex is associated with ribosomes and cotranslationally acetylates human ...
Functional studies of two wild type variants of HIV-1 Tat
(The University of Bergen, 2003)
Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate
The measurement of changes in nicotinic acid adenine dinucleotide phosphate (NAADP) levels in cells has been, and remains, key to the investigation of the functions of NAADP as a Ca2+-releasing second messenger. Here we ...
CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8
CorA is a copper repressible protein previously identified in the methanotrophic bacterium Methylomicrobium album BG8. In this work, we demonstrate that CorA is located on the cell surface and binds one copper ion per ...