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dc.contributor.authorBachou, Hanifaeng
dc.contributor.authorTylleskär, Thorkildeng
dc.contributor.authorKaddu-Mulindwa, Deogratias H.eng
dc.contributor.authorTumwine, James K.eng
dc.date.accessioned2006-11-24T15:46:17Z
dc.date.available2006-11-24T15:46:17Z
dc.date.issued2006-11-07eng
dc.identifier.issn1471-2334eng
dc.identifier.urihttp://hdl.handle.net/1956/1961
dc.description.abstractBackground: To establish the magnitude of bacteraemia in severely malnourished children, and describe the types of bacteria and antimicrobial sensitivity by HIV status. Method: Isolates were recovered from 76 blood specimens. Antibiotic susceptibility tests were performed using commercial antibiotic disks and demographic and clinical findings were recorded. Results: Of the 450 children 63% were male; median age 17.0 months (inter quartile range, IQR 12–24) and 57% had oedema. 151 (36.7 %) of 411 tested HIV-positive; 76 (17.1%) of 445 blood specimens grew bacterial isolates; 58% were Gram negative – S. typhimurium (27.6%) and S. enteriditis (11.8%). Staph. aureus (26.3%) and Strep. pneumoniae (13.2%) were the main Gram positive organisms. There was no difference in the risk of bacteraemia by HIV status, age < 24 months, male sex, or oedema, except for oral thrush (OR 2.3 CI 1.0–5.1) and hypoalbuminaemia (OR 3.5 CI 1.0–12.1). Isolates from severely immuno-suppressed children (CD4% <15%) were more likely to grow Salmonella enteriditis (OR 5.4; CI 1.6 – 17.4). The isolates were susceptible (≥ 80%) to ciprofloxacin, ceftriaxone and gentamicin; with low susceptibility to chlorampenicol, ampicillin (< 50%) and co-trimoxazole (<25%). Suspicion of bacteraemia had 95.9% sensitivity and 99.2% specificity. Among bacteraemic children, mortality was higher (43.5% vs 20.5%) in the HIV-positive; OR 3.0 (95%CI 1.0, 8.6). Conclusion: Bacteraemia affects 1 in every 6 severely malnourished children and carries high mortality especially among the HIV-positive. Given the high level of resistance to common antibiotics, there is need for clinical trials to determine the best combinations of antibiotics for management of bacteraemia in severely malnourished children.en
dc.format.extent258958 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.titleBacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Ugandaeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske Fag: 700::Helsefag: 800nob
dc.subject.nsiVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Generell mikrobiologi: 472nob
dc.rights.holderCopyright 2006 Bachou et al; licensee BioMed Central Ltd.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleBMC Infectious Diseaseseng
bibo.volume6eng
bora.cristinID377306eng
bibo.number160eng
bibo.doihttp://dx.doi.org/10.1186/1471-2334-6-160eng
dc.identifier.cristinID377306eng
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-6-160


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