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A Mouse Model for Latent Tuberculosis

Bergen Open Research Archive

Show simple item record Phyu, S. Mustafa, Tehmina Hofstad, T. Nilsen, Rune Fosse, R. Bjune, Gunnar Aksel 2007-03-18T17:02:33Z 2007-03-18T17:02:33Z 1998-06
dc.identifier.citation Scandinavian journal of infectious diseases 30(1): 59–68
dc.identifier.issn 0036-5548
dc.description.abstract The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens without clinical signs or obvious histopathological changes in the lungs over a long period of time and without spontaneous reactivation of disease. B6D2F1Bom mice were inoculated with a wide range of Mycobacterium tuberculosis doses intraperitoneally or intravenously and followed for a long period to determine suitable conditions to produce latent infection. No anti-tuberculosis drug treatment was used. Microbiological and histopathological studies were carried out. Corticosterone challenge was used to reactivate the latent infection. Mice infected with 4×104 and 4×105 bacilli i.p. were followed up to 107 weeks without spontaneous reactivation. The present model is discussed in comparison with previous latent tuberculosis mouse models as well as the possible mechanisms of shift to stationary phase from multiplying bacilli. en
dc.format.extent 553033 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher Taylor and Francis Ltd. en
dc.rights Copyright 1998 Scandinavian University Press
dc.title A Mouse Model for Latent Tuberculosis en
dc.type Journal article en
dc.type Peer reviewed
dc.subject.nsi VDP::Medisinske Fag: 700::Helsefag: 800 en
dc.type.version publishedVersion
bora.peerreviewed Peer reviewed
bora.journalTitle Scandinavian journal of infectious diseases
bibo.volume 30
bibo.issue 1
bibo.pageStart 59
bibo.pageEnd 68

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