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A Mouse Model for Latent Tuberculosis

Bergen Open Research Archive

Show simple item record Phyu, S. eng Mustafa, Tehmina eng Hofstad, T. eng Nilsen, Rune eng Fosse, R. eng Bjune, Gunnar Aksel eng 2007-03-18T17:02:33Z 2007-03-18T17:02:33Z 1998-06 eng
dc.identifier.citation Scandinavian journal of infectious diseases 30(1): 59–68
dc.identifier.issn 0036-5548 eng
dc.description.abstract The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens without clinical signs or obvious histopathological changes in the lungs over a long period of time and without spontaneous reactivation of disease. B6D2F1Bom mice were inoculated with a wide range of Mycobacterium tuberculosis doses intraperitoneally or intravenously and followed for a long period to determine suitable conditions to produce latent infection. No anti-tuberculosis drug treatment was used. Microbiological and histopathological studies were carried out. Corticosterone challenge was used to reactivate the latent infection. Mice infected with 4×104 and 4×105 bacilli i.p. were followed up to 107 weeks without spontaneous reactivation. The present model is discussed in comparison with previous latent tuberculosis mouse models as well as the possible mechanisms of shift to stationary phase from multiplying bacilli. en
dc.format.extent 553033 bytes eng
dc.format.mimetype application/pdf eng
dc.language.iso eng eng
dc.publisher Taylor and Francis Ltd. eng
dc.title A Mouse Model for Latent Tuberculosis eng
dc.type Journal article eng
dc.subject.nsi VDP::Medisinske Fag: 700::Helsefag: 800 nob
dc.rights.holder Copyright 1998 Scandinavian University Press
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bora.journalTitle Scandinavian Journal of Infectious Diseases eng
bibo.volume 30 eng
bibo.issue 1 eng
bibo.pageStart 59 eng
bibo.pageEnd 68 eng
bibo.doi eng

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