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dc.contributor.authorPhyu, S.eng
dc.contributor.authorMustafa, Tehminaeng
dc.contributor.authorHofstad, T.eng
dc.contributor.authorNilsen, Runeeng
dc.contributor.authorFosse, R.eng
dc.contributor.authorBjune, Gunnar Akseleng
dc.date.accessioned2007-03-18T17:02:33Z
dc.date.available2007-03-18T17:02:33Z
dc.date.issued1998-06eng
dc.identifier.citationScandinavian journal of infectious diseases 30(1): 59–68
dc.identifier.issn0036-5548eng
dc.identifier.urihttp://hdl.handle.net/1956/2155
dc.description.abstractThe aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium tuberculosis count in lungs and spleens without clinical signs or obvious histopathological changes in the lungs over a long period of time and without spontaneous reactivation of disease. B6D2F1Bom mice were inoculated with a wide range of Mycobacterium tuberculosis doses intraperitoneally or intravenously and followed for a long period to determine suitable conditions to produce latent infection. No anti-tuberculosis drug treatment was used. Microbiological and histopathological studies were carried out. Corticosterone challenge was used to reactivate the latent infection. Mice infected with 4×104 and 4×105 bacilli i.p. were followed up to 107 weeks without spontaneous reactivation. The present model is discussed in comparison with previous latent tuberculosis mouse models as well as the possible mechanisms of shift to stationary phase from multiplying bacilli.en
dc.format.extent553033 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherTaylor and Francis Ltd.eng
dc.titleA Mouse Model for Latent Tuberculosiseng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske Fag: 700::Helsefag: 800nob
dc.rights.holderCopyright 1998 Scandinavian University Press
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleScandinavian Journal of Infectious Diseaseseng
bibo.volume30eng
bibo.issue1eng
bibo.pageStart59eng
bibo.pageEnd68eng
bibo.doihttp://dx.doi.org/10.1080/003655498750002321eng
dc.identifier.doihttp://dx.doi.org/10.1080/003655498750002321


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