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Electronmicroscopic study of mineralization in induced heterotopic bone formation in guinea pigs

Bergen Open Research Archive

Show simple item record Nilsen, Rune eng 2007-03-26T15:37:13Z 2007-03-26T15:37:13Z 1980 eng
dc.identifier.citation Scandinavian Journal of Dental Research 88: 340-347
dc.identifier.issn 0029-845x eng
dc.description.abstract Mineralization of heterotopic bone was studied in a bone induction model using allogenic demineralization dentin implanted in the abdominal wall of guinea pigs. There was a high yield of newly formed osteoid and bone as well as some cartilage together with areas of resorption of the dentin, and fibroblast proliferation. The osteoid contained many matrix vesicles II and less of lysosome-like type I vesicles. Early cartilage formation had more type I vesicles. The implanted dentin contained no matrix vesicles. The first sign of mineralization occurred mainly as irregular clusters of mineral crystals in the matrix close to the surface of collagen fibrils. Crystal-like figures were also found inside some type II matrix vesicles, although most of these vesciles in the mineralization zone had no crystals. The type I vesciles of both bone and cartilage exhibited often crystals near the outer membrane. The mineralizing bone showed a reduction in the size and number of proteoglycan particles. Remineralization of the implanted dentin was also often found and the mineralization pattern resembled the mineralization of bone except for the absence of matrix vesicles. Electron diffraction of selected areas showed that the crystals in the new bone and the mineralized dentin were hydroxyapatite. en
dc.format.extent 1402333 bytes eng
dc.format.mimetype application/pdf eng
dc.language.iso eng eng
dc.publisher Munksgaard eng
dc.title Electronmicroscopic study of mineralization in induced heterotopic bone formation in guinea pigs eng
dc.type Journal article eng
dc.subject.nsi VDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830 nob

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