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dc.contributor.authorYahya-Malima, Khadija I.eng
dc.contributor.authorEvjen-Olsen, Bjørgeng
dc.contributor.authorMatee, Mecky I.eng
dc.contributor.authorFylkesnes, Knuteng
dc.contributor.authorHaarr, Larseng
dc.date.accessioned2008-06-25T08:36:34Z
dc.date.available2008-06-25T08:36:34Z
dc.date.issued2008-06-02eng
dc.identifier.citationBMC Infectious Diseases 2008 8(75)en
dc.identifier.issn1471-2334eng
dc.identifier.urihttp://hdl.handle.net/1956/2716
dc.description.abstractBackground: Evidence suggests that a substantial proportion of new HIV infections in African countries are associated with herpes simplex virus type 2 (HSV-2). Thus, the magnitude of HSV-2 infection in an area may suggest the expected course of the HIV epidemic. We determined prevalence of genital herpes, syphilis and associated factors among pregnant women from a remote rural Tanzanian community that has a low but increasing HIV prevalence. Methods: We analysed 1296 sera and responses to a standard structured questionnaire collected from pregnant women aged between 15–49 years, attending six different antenatal clinics within rural Manyara and Singida regions in Tanzania. Linked anonymous testing (with informed consent) of the serum for specific antibodies against HSV-2 was done using a non-commercial peptide- 55 ELISA. Antibodies against syphilis were screened by using rapid plasma reagin (RPR) and reactive samples confirmed by Treponema pallidum haemagglutination assay (TPHA). Results: Previous analysis of the collected sera had shown the prevalence of HIV antibodies to be 2%. In the present study the prevalence of genital herpes and syphilis was 20.7% (95% CI: 18.53–23.00) and 1.6% (95% CI: 1.03–2.51), respectively. The presence of HSV-2 antibodies was associated with polygamy (OR 2.2, 95% CI: 1.62 – 3.01) and the use of contraceptives other than condoms (OR 1.7, 95% CI: 1.21 – 2.41). Syphilis was associated with reporting more than one lifetime sexual partner (OR 5.4, 95% CI: 1.88 – 15.76) and previous spontaneous abortion (OR 4.3, 95% CI: 1.52–12.02). Conclusion: The low prevalence of HIV infection offers a unique opportunity for strengthening HIV prevention in a cost-effective manner. The identification and control of other prevalent curable STIs other than syphilis and specific intervention of HSV-2 in specific populations like pregnant women would be one among approaches towards preventing incident HIV infections.en
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.titleHIV-1, HSV-2 and syphilis among pregnant women in a rural area of Tanzania: Prevalence and risk factorseng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776nob
dc.rights.holderCopyright 2008 Yahya-Malima et al; licensee BioMed Central Ltd.eng
bora.peerreviewedPeer reviewedeng
bora.cristinID336710eng
bibo.doihttp://dx.doi.org/10.1186/1471-2334-8-75eng
dc.identifier.cristinID336710eng
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2334-8-75


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