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dc.contributor.authorBjørkkjær, Tormoden_US
dc.contributor.authorBrun, Johan Gorgasen_US
dc.contributor.authorValen, Mereteen_US
dc.contributor.authorArslan, Gülenen_US
dc.contributor.authorLind, Ragna Anneen_US
dc.contributor.authorBrunborg, Linn Anneen_US
dc.contributor.authorBerstad, Arnolden_US
dc.contributor.authorFrøyland, Livaren_US
dc.date.accessioned2009-11-27T14:27:03Z
dc.date.available2009-11-27T14:27:03Z
dc.date.issued2006-03-20eng
dc.PublishedLipids in Health and Disease 5(6)en
dc.identifier.issn1476-511X
dc.identifier.urihttps://hdl.handle.net/1956/3612
dc.description.abstractBackground: A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10- day) duodenal administration of n-3 polyunsaturated fatty acid rich seal oil ameliorated joint pain in patients with inflammatory bowel disease (IBD). Using unpublished data from these two studies we here investigated whether normalisation of the n-6 to n-3 FA ratio in blood and tissues by seal oil administration was associated with improved health related quality of life (HRQOL) as assessed by the generic short-form 36 (SF-36) questionnaire. Results: In the first pilot study, baseline n-6 to n-3 FA ratio in rectal mucosal biopsies from 10 patients with IBD (9 of those had joint pain) was significantly increased compared with that in 10 control patients without IBD or joint pain. Following seal oil administration, the n-6 to n-3 FA ratio of the IBD-patients was significantly lowered to the level seen in untreated controls. In the subsequent, randomized controlled study (n = 19), seal oil administration reduced the n-6 to n-3 FA ratio in blood similarly and also the SF-36 assessed bodily pain, while n-6 FA rich soy oil administration had no such effect. Conclusion: In these two separate studies, short-term duodenal administration of seal oil normalised the n-6 to n-3 FA ratio in rectal mucosa and improved the bodily pain dimension of HRQOL of patients with IBD-related joint pain. The possibility of a causal relationship between n- 6 to n-3 FA ratio in rectal mucosa and bodily pain in IBD-patients warrants further investigations.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.titleShort-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel diseaseen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderBjørkkjær et al; licensee BioMed Central Ltd
dc.identifier.doihttps://doi.org/10.1186/1476-511x-5-6
dc.identifier.cristin373655
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773nob
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759nob


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