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Diagnostic validity of fatal cerebral strokes and coronary deaths

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dc.contributor.author Gulsvik, Anne K.
dc.contributor.author Gulsvik, Amund
dc.contributor.author Svendsen, Einar
dc.contributor.author Mæhle, Bjørn O.
dc.contributor.author Thelle, Dag S.
dc.contributor.author Wyller, Torgeir B.
dc.date.accessioned 2011-02-10T09:34:25Z
dc.date.available 2011-02-10T09:34:25Z
dc.date.issued 2011-03
dc.identifier.citation European Journal of Epidemiology 26(3): 221-228 en_US
dc.identifier.issn 0393-2990
dc.identifier.uri http://dx.doi.org/10.1007/s10654-010-9535-4
dc.identifier.uri http://hdl.handle.net/1956/4491
dc.description.abstract Mortality statistics represent important endpoints in epidemiological studies. The diagnostic validity of cerebral stroke and ischemic heart disease recorded as the underlying cause of death in Norwegian mortality statistics was assessed by using mortality data of participants in the Bergen Clinical Blood Pressure Study in Norway and autopsy records from the Gade Institute in Bergen. In the 41 years of the study (1965–2005) 4,387 subjects had died and 1,140 (26%) had undergone a post mortem examination; 548 (12%) died from cerebral stroke and 1,120 (24%) from ischemic heart disease according to the mortality statistics, compared to 113 (10%) strokes and 323 (28%) coronary events registered in the autopsy records. The sensitivity and positive predictive value of fatal cerebral strokes in the mortality statistics were 0.75, 95% confidence interval (CI) [0.66, 0.83] and 0.86 [0.77, 0.92], respectively, whereas those of coronary deaths were 0.87 [0.84, 0.91] and 0.85 [0.81, 0.89] respectively. Cohen’s Kappa coefficients were 0.78 [0.72, 0.84] for stroke and 0.80 [0.76, 0.84] for coronary deaths. In addition to female gender and increasing age at death, cerebral stroke was a negative predictor of an autopsy being carried out (odds ratio (OR) 0.69, 95% CI [0.54, 0.87]), whereas death from coronary heart disease was not (OR 1.14, 95% CI [0.97, 1,33]), both adjusted for gender and age at death. There was substantial agreement between mortality statistics and autopsy findings for both fatal strokes and coronary deaths. Selection for post mortem examinations was associated with age, gender and cause of death. en_US
dc.language.iso eng en_US
dc.publisher Springer en
dc.rights Copyright The Author(s) 2010 en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5/ en_US
dc.subject Autopsy en
dc.subject Stroke en
dc.subject Ischemic heart disease en
dc.subject Death certification en
dc.subject Validity en
dc.subject Mortality statistics en
dc.title Diagnostic validity of fatal cerebral strokes and coronary deaths en_US
dc.type Journal article en_US
dc.type Peer reviewed en_US
dc.subject.nsi VDP::Medical disciplines: 700 en_US
dc.type.version publishedVersion en_US
bora.cristinID 842743


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