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Cloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis)

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dc.contributor.author Pinto, Wilson
dc.contributor.author Rønnestad, Ivar
dc.contributor.author Jordal, Ann-Elise Olderbakk
dc.contributor.author Gomes, Ana S.
dc.contributor.author Dinis, Maria Teresa
dc.contributor.author Aragão, Cláudia
dc.date.accessioned 2011-02-24T10:33:13Z
dc.date.available 2011-02-24T10:33:13Z
dc.date.issued 2011
dc.identifier.citation Amino Acids 1-11 en_US
dc.identifier.issn 0939-4451
dc.identifier.issn 1438-2199
dc.identifier.uri http://dx.doi.org/10.1007/s00726-010-0826-6
dc.identifier.uri http://hdl.handle.net/1956/4534
dc.description.abstract Flatfish species seem to require dietary taurine for normal growth and development. Although dietary taurine supplementation has been recommended for flatfish, little is known about the mechanisms of taurine absorption in the digestive tract of flatfish throughout ontogeny. This study described the cloning and ontogenetic expression of the taurine transporter (TauT) in the flatfish Senegalese sole (Solea senegalensis). Results showed a high similarity between TauT in Senegalese sole and other vertebrates, but a change in TauT amino acid sequences indicates that taurine transport may differ between mammals and fish, reptiles or birds. Moreover, results showed that Senegalese sole metamorphosis is an important developmental trigger to promote taurine transport in larvae, especially in muscle tissues, which may be important for larval growth. Results also indicated that the capacity to uptake dietary taurine in the digestive tract is already established in larvae at the onset of metamorphosis. In Senegalese sole juveniles, TauT expression was highest in brain, heart and eye. These are organs where taurine is usually found in high concentrations and is believed to play important biological roles. In the digestive tract of juveniles, TauT was more expressed in stomach and hindgut, indicating that dietary taurine is quickly absorbed when digestion begins and taurine endogenously used for bile salt conjugation may be recycled at the posterior end of the digestive tract. Therefore, these results suggest an enterohepatic recycling pathway for taurine in Senegalese sole, a process that may be important for maintenance of the taurine body levels in flatfish species. en_US
dc.language.iso eng en_US
dc.publisher Springer en
dc.rights Copyright The Author(s) 2011. This article is published with open access at Springerlink.com en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5/ en_US
dc.subject Taurine transporter en
dc.subject TauT–SLC6A6 en
dc.subject Senegalese sole en
dc.subject Flatfish en
dc.subject Ontogeny en
dc.title Cloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis) en_US
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Mathematics and natural science: 400 en_US
dc.rightsHolder The Author(s) 2011 en_US
dc.type.version publishedVersion en_US


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Copyright The Author(s) 2011. This article is published with open access at Springerlink.com Except where otherwise noted, this item's license is described as Copyright The Author(s) 2011. This article is published with open access at Springerlink.com

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