BORA - UiB

Bergen Open Research Archive

The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication

Bergen Open Research Archive

Show simple item record

dc.contributor.author Brügger-Andersen, Trygve eng
dc.contributor.author Bostad, Leif eng
dc.contributor.author Sandnes, Dagny A. eng
dc.contributor.author Larsen, Alf Inge eng
dc.contributor.author Bonarjee, Vernon V. S. eng
dc.contributor.author Barvik, Ståle eng
dc.contributor.author Melberg, Tor eng
dc.contributor.author Nilsen, Dennis W. T. eng
dc.date.accessioned 2011-04-29T06:48:56Z
dc.date.available 2011-04-29T06:48:56Z
dc.date.issued 2010-01-27 eng
dc.identifier.citation Thrombosis Journal 8:1 en_US
dc.identifier.issn 1477-9560 eng
dc.identifier.uri http://hdl.handle.net/1956/4714
dc.description.abstract Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI). Methods The atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis. Results In the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi. Conclusion Our results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC. en_US
dc.language.iso eng eng
dc.rights Attribution CC BY eng
dc.rights.uri http://creativecommons.org/licenses/by/2.0 eng
dc.title The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication eng
dc.type Journal article eng
dc.type Peer reviewed eng
dc.rights.holder Copyright 2010 Brügger-Andersen et al; licensee BioMed Central Ltd.
dc.rights.holder Brügger-Andersen et al. eng
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bora.cristinID 348392 eng
bibo.doi http://dx.doi.org/10.1186/1477-9560-8-1 eng
dc.identifier.cristinID 348392 eng
dc.identifier.doi http://dx.doi.org/10.1186/1477-9560-8-1


Files in this item

 
 

This item appears in the following Collection(s)

Show simple item record

Attribution CC BY Except where otherwise noted, this item's license is described as Attribution CC BY

Search BORA


Browse

My Account