BORA - UiB

Bergen Open Research Archive

The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication

Bergen Open Research Archive

Show simple item record

dc.contributor.author Brügger-Andersen, Trygve
dc.contributor.author Bostad, Leif
dc.contributor.author Sandnes, Dagny A.
dc.contributor.author Larsen, Alf Inge
dc.contributor.author Bonarjee, Vernon V. S.
dc.contributor.author Barvik, Ståle
dc.contributor.author Melberg, Tor
dc.contributor.author Nilsen, Dennis W. T.
dc.date.accessioned 2011-04-29T06:48:56Z
dc.date.available 2011-04-29T06:48:56Z
dc.date.issued 2010-01-27
dc.identifier.citation Thrombosis Journal 8:1 en_US
dc.identifier.issn 1477-9560
dc.identifier.uri http://hdl.handle.net/1956/4714
dc.description.abstract Background The expression of pregnancy-associated plasma protein A (PAPP-A) was identified by immunohistochemistry (IHC) in culprit atherothrombotic plaque specimens harvested from patients admitted with ST-segment elevation myocardial infarction (STEMI). Methods The atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. The atherothrombotic plaques were obtained by aspiration thrombectomy during percutaneous coronary intervention within 12 hours from the onset of symptoms and prepared for IHC analysis. Results In the IHC analysis staining for PAPP-A occurred in the extracellular matrix of the plaques and no evidence of staining for PAPP-A was found in the thrombi. Conclusion Our results indicate that in vivo PAPP-A is strongly expressed in atherothrombotic plaques harvested from patients admitted with STEMI, as documented by IHC. en_US
dc.language.iso eng en_US
dc.rights Copyright 2010 Brügger-Andersen et al; licensee BioMed Central Ltd. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title The activity of pregnancy-associated plasma protein A (PAPP-A) as expressed by immunohistochemistry in atherothrombotic plaques obtained by aspiration thrombectomy in patients presenting with a ST-elevation myocardial infarction: a brief communication en_US
dc.type Journal article en_US
dc.type Peer reviewed en_US
dc.rightsHolder Brügger-Andersen et al. en_US
dc.type.version publishedVersion en_US
bora.cristinID 348392
bibo.doi http://dx.doi.org/10.1186/1477-9560-8-1


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Copyright 2010 Brügger-Andersen et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as Copyright 2010 Brügger-Andersen et al; licensee BioMed Central Ltd.

Search BORA


Browse

My Account