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dc.contributor.authorAarhus, Madseng
dc.contributor.authorLund-Johansen, Morteneng
dc.contributor.authorKnappskog, Pereng
dc.date.accessioned2011-11-23T09:44:11Z
dc.date.available2011-11-23T09:44:11Z
dc.date.issued2011-01-14eng
dc.identifier.citationActa Neurochirurgica 153(3): 447-456en
dc.identifier.issn0001-6268eng
dc.identifier.urihttp://hdl.handle.net/1956/5216
dc.description.abstractPurpose This article provides a review of the transcriptomic expression profiling studies that have been performed on meningiomas so far. We discuss some future prospects and challenges ahead in the field of gene expression profiling. Methods We performed a systematic search in the PubMed and EMBASE databases in May 2010 using the following search terms alone or in combination: “meningioma”, “microarray analysis”, “oligonucleotide array sequence analysis”, or “gene expression profiling”. Only original research articles in English that had used RNA hybridized to high-resolution microarray chips to generate gene expression profiles were included. Results We identified 13 articles matching the inclusion criteria. All studies had been performed during the last decade. Conclusions The main results of the studies can be grouped in three categories: (1) several groups have identified meningioma-specific genes and genes associated with the three WHO grades, and the main histological subtypes of grade I meningiomas; (2) one publication has shown that the general transcription profile of samples of all WHO grades differs in vivo and in vitro; (3) one report provides evidence that microarray technology can be used in an automated fashion to classify tumors. Due to lack of consensus on how microarray data are presented, possible general trends found across the studies are difficult to extract. This could obstruct the discovery of important genes and pathways universally involved in meningioma biology.en
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectMeningiomaeng
dc.subjectMicroarray analysiseng
dc.subjectOligonucleotide array sequence analysiseng
dc.subjectGene expression profilingeng
dc.titleGene expression profiling of meningiomas: current status after a decade of microarray-based transcriptomic studieseng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Other clinical medical disciplines: 799eng
dc.rights.holder©The Author(s) 2011
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bibo.doihttp://dx.doi.org/10.1007/s00701-010-0906-0eng
dc.identifier.doihttp://dx.doi.org/10.1007/s00701-010-0906-0


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