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Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques

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dc.contributor.author Roth, Kjetil
dc.contributor.author Hardie, Jon Andrew
dc.contributor.author Andreassen, Alf H.
dc.contributor.author Leh, Friedemann
dc.contributor.author Eagan, Tomas M. L.
dc.date.accessioned 2011-11-28T09:40:05Z
dc.date.available 2011-11-28T09:40:05Z
dc.date.issued 2008-01-26
dc.identifier.citation BMC Pulmonary Medicine 8(2) en
dc.identifier.issn 1471-2466
dc.identifier.uri http://dx.doi.org/doi:10.1186/1471-2466-8-2
dc.identifier.uri http://hdl.handle.net/1956/5232
dc.description.abstract Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were to find the predictors of diagnostic yield in bronchoscopy and to evaluate different combinations of sampling techniques. Methods: All bronchoscopies performed on suspicion of lung malignancy in 2003 and 2004 were reviewed, and 363 patients with proven malignant lung disease were included in the study. Sampling techniques performed were biopsy, transbronchial needle aspiration (TBNA), brushing, small volume lavage (SVL), and aspiration of fluid from the entire procedure. Logistic regression analyses were adjusted for sex, age, endobronchial visibility, localization (lobe), distance from carina, and tumor size. Results: The adjusted odds ratios (OR) with 95% confidence intervals (CI) for a positive diagnostic yield through all procedures were 17.0 (8.5–34.0) for endobronchial lesions, and 2.6 (1.3–5.2) for constriction/compression, compared to non-visible lesions; 3.8 (1.3–10.7) for lesions > 4 cm, 6.7 (2.1–21.8) for lesions 3–4 cm, and 2.5 (0.8–7.9) for lesions 2–3 cm compared with lesions <= 2 cm. The combined diagnostic yield of biopsy and TBNA was 83.7% for endobronchial lesions and 54.2% for the combined group without visible lesions. This was superior to either technique alone, whereas additional brushing, SVL, and aspiration did not significantly increase the diagnostic yield. Conclusion: In patients with malignant lung disease, visible lesions and larger tumor size were significant predictors of higher diagnostic yield, after adjustment for sex, age, distance from carina, side and lobe. The combined diagnostic yield of biopsy and TBNA was significant higher than with either technique alone. en
dc.language.iso eng en
dc.publisher BioMed Central en
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5234" target="blank">Bronchoscopy of lesions suspicious of malignancy: Predictors of a higher diagnostic yield, the optimal combination of sampling techniques, and evaluation of endobronchial ultrasound with a rotating miniprobe. A retrospective cohort study and a prospective open randomised real-life study among physicians with various levels of experience</a> en
dc.rights © 2008 Roth et al; licensee BioMed Central Ltd en
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ en
dc.title Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques en
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 en
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 en
dc.type.version publishedVersion en


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© 2008 Roth et al; licensee BioMed Central Ltd Except where otherwise noted, this item's license is described as © 2008 Roth et al; licensee BioMed Central Ltd

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