BORA - UiB

Bergen Open Research Archive

Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques

Bergen Open Research Archive

Show simple item record

dc.contributor.author Roth, Kjetil eng
dc.contributor.author Hardie, Jon Andrew eng
dc.contributor.author Andreassen, Alf H. eng
dc.contributor.author Leh, Friedemann eng
dc.contributor.author Eagan, Tomas Mikal eng
dc.date.accessioned 2011-11-28T09:40:05Z
dc.date.available 2011-11-28T09:40:05Z
dc.date.issued 2008-01-26 eng
dc.identifier.citation BMC Pulmonary Medicine 8(2) en
dc.identifier.issn 1471-2466 eng
dc.identifier.uri http://hdl.handle.net/1956/5232
dc.description.abstract Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were to find the predictors of diagnostic yield in bronchoscopy and to evaluate different combinations of sampling techniques. Methods: All bronchoscopies performed on suspicion of lung malignancy in 2003 and 2004 were reviewed, and 363 patients with proven malignant lung disease were included in the study. Sampling techniques performed were biopsy, transbronchial needle aspiration (TBNA), brushing, small volume lavage (SVL), and aspiration of fluid from the entire procedure. Logistic regression analyses were adjusted for sex, age, endobronchial visibility, localization (lobe), distance from carina, and tumor size. Results: The adjusted odds ratios (OR) with 95% confidence intervals (CI) for a positive diagnostic yield through all procedures were 17.0 (8.5–34.0) for endobronchial lesions, and 2.6 (1.3–5.2) for constriction/compression, compared to non-visible lesions; 3.8 (1.3–10.7) for lesions > 4 cm, 6.7 (2.1–21.8) for lesions 3–4 cm, and 2.5 (0.8–7.9) for lesions 2–3 cm compared with lesions <= 2 cm. The combined diagnostic yield of biopsy and TBNA was 83.7% for endobronchial lesions and 54.2% for the combined group without visible lesions. This was superior to either technique alone, whereas additional brushing, SVL, and aspiration did not significantly increase the diagnostic yield. Conclusion: In patients with malignant lung disease, visible lesions and larger tumor size were significant predictors of higher diagnostic yield, after adjustment for sex, age, distance from carina, side and lobe. The combined diagnostic yield of biopsy and TBNA was significant higher than with either technique alone. en
dc.language.iso eng eng
dc.publisher BioMed Central eng
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5234" target="blank">Bronchoscopy of lesions suspicious of malignancy: Predictors of a higher diagnostic yield, the optimal combination of sampling techniques, and evaluation of endobronchial ultrasound with a rotating miniprobe. A retrospective cohort study and a prospective open randomised real-life study among physicians with various levels of experience</a> eng
dc.rights Attribution CC BY eng
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ eng
dc.title Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques eng
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 eng
dc.rights.holder © 2008 Roth et al; licensee BioMed Central Ltd
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bibo.doi http://dx.doi.org/doi:10.1186/1471-2466-8-2 eng
dc.identifier.doi http://dx.doi.org/doi:10.1186/1471-2466-8-2
dcterms.isPartOf http://hdl.handle.net/1956/5234


Files in this item

 

This item appears in the following Collection(s)

Show simple item record

Attribution CC BY Except where otherwise noted, this item's license is described as Attribution CC BY

Search BORA


Browse

My Account