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dc.contributor.authorAarsetøy, Hildegunnen_US
dc.contributor.authorAarsetøy, Reidunen_US
dc.contributor.authorLindner, Thomas Werneren_US
dc.contributor.authorStaines, Harryen_US
dc.contributor.authorHarris, William S.en_US
dc.contributor.authorNilsen, Dennis W. T.en_US
dc.date.accessioned2011-11-29T10:45:19Z
dc.date.available2011-11-29T10:45:19Z
dc.date.issued2011-01-14eng
dc.PublishedLipids 46(2): 151-161en
dc.identifier.issn0024-4201
dc.identifier.urihttps://hdl.handle.net/1956/5248
dc.description.abstractIn previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) expressed as weight percentage of total FA) has recently been proposed as a new risk factor for death from coronary artery disease, especially following sudden cardiac arrest (SCA). As blood samples often haven been harvested after the event, the aim of our study was to evaluate the stability of RBC fatty acids following SCA. The total FA profile, including the omega-3 index, was measured three times during the first 48 h in 25 survivors of out-of-hospital cardiac arrest (OHCA), in 15 patients with a myocardial infarction (MI) without SCA and in 5 healthy subjects. We could not demonstrate significant changes in the FA measurements in any of the groups, this also applied to the omega-6/omega-3 ratio and the arachidonic acid (AA)/EPA ratio. Furthermore, we compared the omega-3 index in 14 OHCA-patients suffering their first MI with that of 185 first-time MI-patients without SCA; mean values being 4.59% and 6.48%, respectively (p = 0.002). In a multivariate logistic regression analysis, a 1% increase of the omega-3 index was associated with a 58% (95% CI: 0.25–0.76%) reduction in risk of ventricular fibrillation (VF). In conclusion, the omega-3 index remained stable after an event of SCA and predicted the risk of VF.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution-NonCommercial 4.0 Internasjonal
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.noeng
dc.subjectSudden cardiac arresteng
dc.subjectMyocardial infarctioneng
dc.subjectVentricular fibrillationeng
dc.titleLow Levels of the Omega-3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phaseen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderThe Author(s) 2011
dc.identifier.doihttps://doi.org/10.1007/s11745-010-3511-3
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771eng


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Attribution-NonCommercial 4.0 Internasjonal
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