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dc.contributor.authorDinkelacker, V.eng
dc.contributor.authorGrüter, M.eng
dc.contributor.authorKlaver, P.eng
dc.contributor.authorGrüter, T.eng
dc.contributor.authorSpecht, Karsteneng
dc.contributor.authorWeis, S.eng
dc.contributor.authorKennerknecht, I.eng
dc.contributor.authorElger, C. E.eng
dc.contributor.authorFernandez, G.eng
dc.date.accessioned2011-11-29T12:23:35Z
dc.date.available2011-11-29T12:23:35Z
dc.date.issued2010-12-01eng
dc.identifier.citationJournal of Neurology 258(59: 770-782en
dc.identifier.issn0340-5354eng
dc.identifier.urihttp://hdl.handle.net/1956/5254
dc.description.abstractFace recognition is a primary social skill which depends on a distributed neural network. A pronounced face recognition deficit in the absence of any lesion is seen in congenital prosopagnosia. This study investigating 24 congenital prosopagnosic subjects and 25 control subjects aims at elucidating its neural basis with fMRI and voxelbased morphometry. We found a comprehensive behavioral pattern, an impairment in visual recognition for faces and buildings that spared long-term memory for faces with negative valence. Anatomical analysis revealed diminished gray matter density in the bilateral lingual gyrus, the right middle temporal gyrus, and the dorsolateral prefrontal cortex. In most of these areas, gray matter density correlated with memory success. Decreased functional activation was found in the left fusiform gyrus, a crucial area for face processing, and in the dorsolateral prefrontal cortex, whereas activation of the medial prefrontal cortex was enhanced. Hence, our data lend strength to the hypothesis that congenital prosopagnosia is explained by network dysfunction and suggest that anatomic curtailing of visual processing in the lingual gyrus plays a substantial role. The dysfunctional circuitry further encompasses the fusiform gyrus and the dorsolateral prefrontal cortex, which may contribute to their difficulties in long-term memory for complex visual information. Despite their deficits in face identity recognition, processing of emotion related information is preserved and possibly mediated by the medial prefrontal cortex. Congenital prosopagnosia may, therefore, be a blueprint of differential curtailing in networks of visual cognition.en
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectCongenital prosopagnosiaeng
dc.subjectFusiform gyruseng
dc.subjectVoxel-based morphometryeng
dc.titleCongenital prosopagnosia: multistage anatomical and functional deficits in face processing circuitryeng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752eng
dc.rights.holder©The Author(s) 2011
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bibo.doihttp://dx.doi.org/10.1007/s00415-010-5828-5eng
dc.identifier.doihttp://dx.doi.org/10.1007/s00415-010-5828-5


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