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Vaccination coverage and timeliness in three South African areas: a prospective study

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dc.contributor.author Fadnes, Lars Thore
dc.contributor.author Jackson, Debra
dc.contributor.author Engebretsen, Ingunn Marie S.
dc.contributor.author Zembe, Wanga
dc.contributor.author Sanders, David
dc.contributor.author Sommerfelt, Halvor
dc.contributor.author Tylleskär, Thorkild
dc.date.accessioned 2012-01-20T12:36:14Z
dc.date.available 2012-01-20T12:36:14Z
dc.date.issued 2011-05-27
dc.identifier.citation BMC Public Health 2011, 11:404 en
dc.identifier.issn 1471-2458
dc.identifier.uri http://dx.doi.org/10.1186/1471-2458-11-404
dc.identifier.uri http://hdl.handle.net/1956/5477
dc.description.abstract Background: Timely vaccination is important to induce adequate protective immunity. We measured vaccination timeliness and vaccination coverage in three geographical areas in South Africa. Methods: This study used vaccination information from a community-based cluster-randomized trial promoting exclusive breastfeeding in three South African sites (Paarl in the Western Cape Province, and Umlazi and Rietvlei in KwaZulu-Natal) between 2006 and 2008. Five interview visits were carried out between birth and up to 2 years of age (median follow-up time 18 months), and 1137 children were included in the analysis. We used Kaplan-Meier time-to-event analysis to describe vaccination coverage and timeliness in line with the Expanded Program on Immunization for the first eight vaccines. This included Bacillus Calmette-Guérin (BCG), four oral polio vaccines and 3 doses of the pentavalent vaccine which protects against diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae type B. Results: The proportion receiving all these eight recommended vaccines were 94% in Paarl (95% confidence interval [CI] 91-96), 62% in Rietvlei (95%CI 54-68) and 88% in Umlazi (95%CI 84-91). Slightly fewer children received all vaccines within the recommended time periods. The situation was worst for the last pentavalent- and oral polio vaccines. The hazard ratio for incomplete vaccination was 7.2 (95%CI 4.7-11) for Rietvlei compared to Paarl. Conclusions: There were large differences between the different South African sites in terms of vaccination coverage and timeliness, with the poorer areas of Rietvlei performing worse than the better-off areas in Paarl. The vaccination coverage was lower for the vaccines given at an older age. There is a need for continued efforts to improve vaccination coverage and timeliness, in particular in rural areas. en
dc.language.iso eng en
dc.publisher BioMed Central en
dc.rights Copyright 2011 Fadnes et al; licensee BioMed Central Ltd. en
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ en
dc.title Vaccination coverage and timeliness in three South African areas: a prospective study en
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 en
dc.type.version publishedVersion en


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Copyright 2011 Fadnes et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as Copyright 2011 Fadnes et al; licensee BioMed Central Ltd.

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