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dc.contributor.authorHestvik, Elineng
dc.contributor.authorTumwine, James K.eng
dc.contributor.authorTylleskär, Thorkildeng
dc.contributor.authorGrahnquist, Lenaeng
dc.contributor.authorNdeezi, Graceeng
dc.contributor.authorKaddu-Mulindwa, Deogratias H.eng
dc.contributor.authorAksnes, Lageeng
dc.contributor.authorOlafsdottir, Eddaeng
dc.date.accessioned2012-01-20T15:01:00Z
dc.date.available2012-01-20T15:01:00Z
dc.date.issued2011-02-02eng
dc.identifier.citationBMC Pediatrics 2011, 11:9en
dc.identifier.issn1471-2431eng
dc.identifier.urihttp://hdl.handle.net/1956/5484
dc.description.abstractBackground: Calprotectin is a calcium and zinc binding protein, abundant in neutrophils and is extremely stable in faeces. Faecal calprotectin is used as a non-specific marker for gastrointestinal inflammation. It has a good diagnostic precision to distinguish between irritable bowel syndrome and inflammatory bowel disease. Studies have established normal concentrations in healthy children; all these studies have been performed in high-income countries. The objective of this study was to determine the concentration of faecal calprotectin in apparently healthy children aged 0-12 years in urban Kampala, Uganda. Method: We tested 302 apparently healthy children aged, age 0-12 years (162 female, 140 male) in urban Kampala, Uganda. The children were recruited consecutively by door-to-door visits. Faecal calprotectin was analyzed using a quantitative enzyme-linked immunosorbent assay. Faeces were also tested for Helicobacter pylori (H. pylori) antigen, for growth of enteropathogens and microscopy was performed to assess protozoa and helminths. A short standardized interview with socio-demographic information and medical history was obtained to assess health status of the children. Results: In the different age groups the median faecal calprotectin concentrations were 249 mg/kg in 0 < 1 year (n = 54), 75 mg/kg in 1 < 4 years (n = 89) and 28 mg/kg in 4 < 12 years (n = 159). There was no significant difference in faecal calprotectin concentrations and education of female caretaker, wealth index, gender, habits of using mosquito nets, being colonized with H. pylori or having other pathogens in the stool. Conclusion: Concentrations of faecal calprotectin among healthy children, living in urban Ugandan, a low-income country, are comparable to those in healthy children living in high-income countries. In children older than 4 years, the faecal calprotectin concentration is low. In healthy infants faecal calprotectin is high. The suggested cut-off concentrations in the literature can be used in apparently healthy Ugandan children. This finding also shows that healthy children living under poor circumstances do not have a constant inflammation in the gut. We see an opportunity to use this relatively inexpensive test for further understanding and investigations of gut inflammation in children living in low-income countries.en
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/5732" target="blank">Helicobacter pylori and faecal calprotectin in apparently healthy and HIV-infected Ugandan children</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/eng
dc.titleFaecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based surveyeng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760eng
dc.subject.nsiVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801eng
dc.rights.holderCopyright 2011 Hestvik et al; licensee BioMed Central Ltd.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.cristinID804157eng
bibo.doihttp://dx.doi.org/10.1186/1471-2431-11-9eng
dc.identifier.cristinID804157eng
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2431-11-9
dcterms.isPartOfhttp://hdl.handle.net/1956/5732


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