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Gene expression in the rat brain: High similarity but unique differences between frontomedial-, temporal- and occipital cortex

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dc.contributor.author Stansberg, Christine eng
dc.contributor.author Ersland, Kari Merete eng
dc.contributor.author Valk, Paul van der eng
dc.contributor.author Steen, Vidar Martin eng
dc.date.accessioned 2012-01-24T09:40:49Z
dc.date.available 2012-01-24T09:40:49Z
dc.date.issued 2011-01-26 eng
dc.identifier.citation BMC Neuroscience 2011, 12:15 en
dc.identifier.issn 1471-2202 eng
dc.identifier.uri http://hdl.handle.net/1956/5514
dc.description.abstract Background: The six-layered neocortex of the mammalian brain may appear largely homologous, but is in reality a modular structure of anatomically and functionally distinct areas. However, global gene expression seems to be almost identical across the cerebral cortex and only a few genes have so far been reported to show regional enrichment in specific cortical areas. Results: In the present study on adult rat brain, we have corroborated the strikingly similar gene expression among cortical areas. However, differential expression analysis has allowed for the identification of 30, 24 and 11 genes enriched in frontomedial -, temporal- or occipital cortex, respectively. A large proportion of these 65 genes appear to be involved in signal transduction, including the ion channel Fxyd6, the neuropeptide Grp and the nuclear receptor Rorb. We also find that the majority of these genes display increased expression levels around birth and show distinct preferences for certain cortical layers and cell types in rodents. Conclusions: Since specific patterns of expression often are linked to equally specialised biological functions, we propose that these cortex sub-region enriched genes are important for proper functioning of the cortical regions in question. en
dc.language.iso eng eng
dc.publisher BioMed Central eng
dc.relation.ispartof <a href="http://hdl.handle.net/1956/6267" target="blank">Identification and characterisation of regionally enriched cortex genes in the rat brain</a> eng
dc.rights Attribution CC BY eng
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ eng
dc.title Gene expression in the rat brain: High similarity but unique differences between frontomedial-, temporal- and occipital cortex eng
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 eng
dc.rights.holder Copyright 2011 Stansberg et al; licensee BioMed Central Ltd.
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bora.cristinID 830088 eng
bibo.doi http://dx.doi.org/10.1186/1471-2202-12-15 eng
dc.identifier.cristinID 830088 eng
dc.identifier.doi http://dx.doi.org/10.1186/1471-2202-12-15
dcterms.isPartOf http://hdl.handle.net/1956/6267


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