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dc.contributor.authorStansberg, Christineeng
dc.contributor.authorErsland, Kari Mereteeng
dc.contributor.authorValk, Paul van dereng
dc.contributor.authorSteen, Vidar Martineng
dc.date.accessioned2012-01-24T09:40:49Z
dc.date.available2012-01-24T09:40:49Z
dc.date.issued2011-01-26eng
dc.identifier.citationBMC Neuroscience 2011, 12:15en
dc.identifier.issn1471-2202eng
dc.identifier.urihttp://hdl.handle.net/1956/5514
dc.description.abstractBackground: The six-layered neocortex of the mammalian brain may appear largely homologous, but is in reality a modular structure of anatomically and functionally distinct areas. However, global gene expression seems to be almost identical across the cerebral cortex and only a few genes have so far been reported to show regional enrichment in specific cortical areas. Results: In the present study on adult rat brain, we have corroborated the strikingly similar gene expression among cortical areas. However, differential expression analysis has allowed for the identification of 30, 24 and 11 genes enriched in frontomedial -, temporal- or occipital cortex, respectively. A large proportion of these 65 genes appear to be involved in signal transduction, including the ion channel Fxyd6, the neuropeptide Grp and the nuclear receptor Rorb. We also find that the majority of these genes display increased expression levels around birth and show distinct preferences for certain cortical layers and cell types in rodents. Conclusions: Since specific patterns of expression often are linked to equally specialised biological functions, we propose that these cortex sub-region enriched genes are important for proper functioning of the cortical regions in question.en
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/6267" target="blank">Identification and characterisation of regionally enriched cortex genes in the rat brain</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/eng
dc.titleGene expression in the rat brain: High similarity but unique differences between frontomedial-, temporal- and occipital cortexeng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752eng
dc.rights.holderCopyright 2011 Stansberg et al; licensee BioMed Central Ltd.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.cristinID830088eng
bibo.doihttp://dx.doi.org/10.1186/1471-2202-12-15eng
dc.identifier.cristinID830088eng
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2202-12-15
dcterms.isPartOfhttp://hdl.handle.net/1956/6267


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Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY