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Prevalence of Helicobacter pylori in HIV-infected, HAART-naïve Ugandan children: a hospital-based survey

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dc.contributor.author Hestvik, Elin
dc.contributor.author Tylleskär, Thorkild
dc.contributor.author Ndeezi, Grace
dc.contributor.author Grahnquist, Lena
dc.contributor.author Olafsdottir, Edda
dc.contributor.author Tumwine, James K.
dc.contributor.author Kaddu-Mulindwa, Deogratias H.
dc.date.accessioned 2012-02-06T13:40:27Z
dc.date.available 2012-02-06T13:40:27Z
dc.date.issued 2011-06-30
dc.identifier.citation Journal of the International AIDS Society 2011, 14:34 en
dc.identifier.issn 1758-2652
dc.identifier.uri http://dx.doi.org/10.1186/1758-2652-14-34
dc.identifier.uri http://hdl.handle.net/1956/5559
dc.description.abstract Background: The aim of this survey was to determine the prevalence of and factors associated with Helicobacter pylori (H. pylori) colonization in HIV-infected, highly active antiretroviral therapy-naïve Ugandan children aged 0-12 years. Methods: In a hospital-based survey, 236 HIV-infected children were tested for H. pylori colonization using a faecal antigen test. A standardized interview with socio-demographic information and medical history was used to assess risk factors. A cluster of differentiation 4 (CD4) cell percentage was prevalent in most children. Results: The overall prevalence of H. pylori in the HIV-infected children was 22.5%. Age-specific prevalence was as follows: up to one year, 14.7%; 1-3 years, 30.9%; and 3-12 years, 20.7%. HIV-infected children who were more seriously affected by their disease (low CD4 cell percentage or WHO clinical stage II-IV) were less likely to be colonized with H. pylori. There was a trend for a lower prevalence of H. pylori in children who had taken antibiotics for the preceding two weeks (21.6%) than in those who had not taken antibiotics (35.7%). There was no statistically significant difference in prevalence by gender, housing, congested living, education of the female caretaker, drinking water or toilet facilities. Conclusions: HIV-infected, HAART-naïve Ugandan children had a lower prevalence of H. pylori colonization compared with apparently healthy Ugandan children (44.3%). Children with a low CD4 cell percentage and an advanced clinical stage of HIV had an even lower risk of H. pylori colonization. Treatment with antibiotics due to co-morbidity with infectious diseases is a possible explanation for the relatively low prevalence. en
dc.language.iso eng en
dc.publisher BioMed Central en
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5732" target="blank">Helicobacter pylori and faecal calprotectin in apparently healthy and HIV-infected Ugandan children</a> en
dc.rights Copyright 2011 Hestvik et al; licensee BioMed Central Ltd. en
dc.rights.uri http://creativecommons.org/licenses/by/2.0/ en
dc.title Prevalence of Helicobacter pylori in HIV-infected, HAART-naïve Ugandan children: a hospital-based survey en
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 en
dc.type.version publishedVersion en


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Copyright 2011 Hestvik et al; licensee BioMed Central Ltd. Except where otherwise noted, this item's license is described as Copyright 2011 Hestvik et al; licensee BioMed Central Ltd.

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