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dc.contributor.authorHestvik, Elineng
dc.contributor.authorTylleskär, Thorkildeng
dc.contributor.authorNdeezi, Graceeng
dc.contributor.authorGrahnquist, Lenaeng
dc.contributor.authorOlafsdottir, Eddaeng
dc.contributor.authorTumwine, James K.eng
dc.contributor.authorKaddu-Mulindwa, Deogratias H.eng
dc.date.accessioned2012-02-06T13:40:27Z
dc.date.available2012-02-06T13:40:27Z
dc.date.issued2011-06-30eng
dc.identifier.citationJournal of the International AIDS Society 2011, 14:34en
dc.identifier.issn1758-2652eng
dc.identifier.urihttp://hdl.handle.net/1956/5559
dc.description.abstract<p>Background: The aim of this survey was to determine the prevalence of and factors associated with Helicobacter pylori (H. pylori) colonization in HIV-infected, highly active antiretroviral therapy-naïve Ugandan children aged 0-12 years.</p> <p>Methods: In a hospital-based survey, 236 HIV-infected children were tested for H. pylori colonization using a faecal antigen test. A standardized interview with socio-demographic information and medical history was used to assess risk factors. A cluster of differentiation 4 (CD4) cell percentage was prevalent in most children.</p> <p>Results: The overall prevalence of H. pylori in the HIV-infected children was 22.5%. Age-specific prevalence was as follows: up to one year, 14.7%; 1-3 years, 30.9%; and 3-12 years, 20.7%. HIV-infected children who were more seriously affected by their disease (low CD4 cell percentage or WHO clinical stage II-IV) were less likely to be colonized with H. pylori. There was a trend for a lower prevalence of H. pylori in children who had taken antibiotics for the preceding two weeks (21.6%) than in those who had not taken antibiotics (35.7%). There was no statistically significant difference in prevalence by gender, housing, congested living, education of the female caretaker, drinking water or toilet facilities.</p> <p>Conclusions: HIV-infected, HAART-naïve Ugandan children had a lower prevalence of H. pylori colonization compared with apparently healthy Ugandan children (44.3%). Children with a low CD4 cell percentage and an advanced clinical stage of HIV had an even lower risk of H. pylori colonization. Treatment with antibiotics due to co-morbidity with infectious diseases is a possible explanation for the relatively low prevalence.</p>en
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/5732" target="blank">Helicobacter pylori and faecal calprotectin in apparently healthy and HIV-infected Ugandan children</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/eng
dc.titlePrevalence of Helicobacter pylori in HIV-infected, HAART-naïve Ugandan children: a hospital-based surveyeng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801eng
dc.rights.holderCopyright 2011 Hestvik et al; licensee BioMed Central Ltd.
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.cristinID877815eng
bibo.doihttp://dx.doi.org/10.1186/1758-2652-14-34eng
dc.identifier.cristinID877815eng
dc.identifier.doihttp://dx.doi.org/10.1186/1758-2652-14-34
dcterms.isPartOfhttp://hdl.handle.net/1956/5732


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