Show simple item record

dc.contributor.authorArnesen, Thomaseng
dc.identifier.citationPLoS Biology 9(5): e1001074en
dc.description.abstractProtein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein–protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come.en
dc.publisherPublic Library of Scienceeng
dc.rightsAttribution CC BYeng
dc.titleTowards a Functional Understanding of Protein NTerminal Acetylationeng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Mathematics and natural science: 400::Basic biosciences: 470eng
dc.rights.holderCopyright 2011 Thomas Arnesen
bora.peerreviewedPeer reviewedeng

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY