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Towards a Functional Understanding of Protein NTerminal Acetylation

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dc.contributor.author Arnesen, Thomas
dc.date.accessioned 2012-02-20T11:15:16Z
dc.date.available 2012-02-20T11:15:16Z
dc.date.issued 2011-05-31
dc.identifier.citation PLoS Biology 9(5): e1001074 en
dc.identifier.issn 1544-9173
dc.identifier.uri http://dx.doi.org/10.1371/journal.pbio.1001074
dc.identifier.uri http://hdl.handle.net/1956/5621
dc.description.abstract Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation of protein–protein interactions and targeting to membranes, as demonstrated by studies of a handful of proteins. Fifty years after its discovery, a potential general function of the N-terminal acetyl group carried by thousands of unique proteins remains enigmatic. However, recent functional data suggest roles for N-terminal acetylation as a degradation signal and as a determining factor for preventing protein targeting to the secretory pathway, thus highlighting N-terminal acetylation as a major determinant for the life and death of proteins. These contributions represent new and intriguing hypotheses that will guide the research in the years to come. en
dc.language.iso eng en
dc.publisher Public Library of Science en
dc.rights Copyright 2011 Thomas Arnesen en
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ en
dc.title Towards a Functional Understanding of Protein NTerminal Acetylation en
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Mathematics and natural science: 400::Basic biosciences: 470 en
dc.type.version publishedVersion en


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