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Low Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndrome

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dc.contributor.author El-Salhy, Magdy eng
dc.contributor.author Gundersen, Doris eng
dc.contributor.author Østgaard, Hege eng
dc.contributor.author Lomholt-Beck, B. eng
dc.contributor.author Hatlebakk, Jan Gunnar eng
dc.contributor.author Hausken, Trygve eng
dc.date.accessioned 2012-04-16T09:53:32Z
dc.date.available 2012-04-16T09:53:32Z
dc.date.issued 2011-11-05 eng
dc.identifier.citation Digestive Diseases and Sciences 57(4): 873-878 en
dc.identifier.issn 0163-2116 eng
dc.identifier.uri http://hdl.handle.net/1956/5749
dc.description.abstract Background The gut hormones are important in regulating gastrointestinal motility. Disturbances in gastrointestinal motility have been reported in patients with irritable bowel syndrome (IBS). Reduced endocrine cell density, as revealed by chromogranin A, has been reported in the colon of IBS patients. Aims To investigate a possible abnormality in the colonic endocrine cells of IBS patients. Methods A total of 41 patients with IBS according to Rome Criteria III and 20 controls were included in the study. Biopsies from the right and left colon were obtained from both patients and controls during colonoscopy. The biopsies were immunostained for serotonin, peptide YY (PYY), pancreatic polypeptide (PP), entroglucagon, and somatostatin cells. Cell densities were quantified by computerized image analysis. Results Serotonin and PYY cell densities were reduced in the colon of IBS patients. PP, entroglucagon, and somatostatin- immunoreactive cells were too few to enable reliable quantification. en
dc.language.iso eng eng
dc.publisher Springer eng
dc.rights.uri http://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0 eng
dc.subject Colon eng
dc.subject Immunohistochemistry eng
dc.title Low Densities of Serotonin and Peptide YY Cells in the Colon of Patients with Irritable Bowel Syndrome eng
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773 eng
dc.rights.holder Copyright the Author(s) 2011
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bibo.doi http://dx.doi.org/10.1007/s10620-011-1948-8 eng
dc.identifier.doi http://dx.doi.org/10.1007/s10620-011-1948-8


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