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dc.contributor.authorEikeland, Randieng
dc.contributor.authorLjøstad, Unneng
dc.contributor.authorMygland, Åseeng
dc.contributor.authorHerlofson, Kareneng
dc.contributor.authorLøhaugen, G. C.eng
dc.date.accessioned2012-07-02T11:14:10Z
dc.date.available2012-07-02T11:14:10Z
dc.date.issued2011eng
dc.identifier.citationEuropean Journal of Neurology 19(3): 480-87en
dc.identifier.issn1351-5101eng
dc.identifier.urihttp://hdl.handle.net/1956/5868
dc.description.abstractBackground: The aim of this study was to compare neuropsychological (NP) functioning in patients with Lyme neuroborreliosis (LNB) 30 months after treatment to matched controls. Methods: We tested 50 patients with LNB and 50 controls with the trail-making test (TMT), Stroop test, digit symbol test, and California Verbal Learning test (CVLT). A global NP sumscore was calculated to express the number of low scores on 23 NP subtasks. Results: Mean scores were lower amongst LNB-treated patients than amongst controls on tasks assessing attention/executive functions: (Stroop test 4: 77.6 vs. 67.0, P = 0.015), response/processing speed (TMT 5: 23.4 vs. 19.2, P = 0.004), visual memory (digit symbol recall: 6.6 vs. 7.2, P = 0.038), and verbal memory (CVLT list B: 4.68 vs. 5.50, P = 0.003). The proportion of patients and controls with NP sumscores within one SD from the mean in the control group (defined as normal) and between one and two SD (defined as deficit) were similar, but more LNB-treated patients than controls had a sumscore more than two SD from the mean (defined as impairment) (8 vs. 1, P = 0.014). Conclusions: As a group, LNB-treated patients scored lower on four NP subtasks assessing processing speed, visual and verbal memory, and executive/attention functions, as compared to matched controls. The distribution of NP dysfunctions indicates that most LNB-treated patients perform comparable to controls, whilst a small subgroup have a debilitating long-term course with cognitive problems.en
dc.language.isoengeng
dc.publisherJohn Wiley & Sons, Inc.eng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/5870" target="blank">European neuroborreliosis: Long term follow-up</a>eng
dc.subjectCognitioneng
dc.subjectexecutive functionseng
dc.subjectLyme diseaseeng
dc.subjectLyme neuroborreliosiseng
dc.subjectMemoryeng
dc.titleEuropean neuroborreliosis: neuropsychological findings 30 months post-treatmenteng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752eng
dc.rights.holderCopyright 2011 The Author(s). European Journal of Neurology Copyright 2011 EFNS.
dc.type.versionacceptedVersioneng
bora.peerreviewedPeer reviewedeng
bora.cristinID927732eng
bibo.doihttp://dx.doi.org/10.1111/j.1468-1331.2011.03563.xeng
dc.identifier.cristinID927732eng
dc.identifier.doihttp://dx.doi.org/10.1111/j.1468-1331.2011.03563.x
dcterms.isPartOfhttp://hdl.handle.net/1956/5870


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