Now showing items 1-10 of 63
Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers
(BioMed Central, 2010-07-01)
Background The tumor suppressor pRb plays a key role regulating cell cycle arrest, and disturbances in the RB1 gene have been reported in different cancer forms. However, the literature reports contradictory findings with ...
Maternal, paternal and temperature effects on otolith size of young herring (Clupea harengus L.) larvae: an experimental study
(The University of Bergen, 1997)
NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation
(Public Library of Science, 2011-07-07)
N-terminal acetylation (N-Ac) is a highly abundant eukaryotic protein modification. Proteomics revealed a significant increase in the occurrence of N-Ac from lower to higher eukaryotes, but evidence explaining the underlying ...
Sedation and slaughter of Atlantic salmon (Salmo salar, L.) with carbon monoxide, and a possible regulatory role of neuroglobin
(The University of Bergen, 2012-10-05)
<p>Until recently CO2 has been utilized as an anesthetic method before gill cutting of Norwegian Atlantic salmon farmed fish. From 1. July 2012 this is no longer permitted in Norway since it causes strong aversive reactions ...
Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: When aromatic amino acids matter
Neutrophil serine proteases Proteinase 3 (PR3) and human neutrophil elastase (HNE) are homologous antibiotic serine proteases of the polymorphonuclear neutrophils. Despite sharing a 56% sequence identity they have been ...
Analysis of transcription factor complexes and their associated chromatin interactions during erythropoiesis
(The University of Bergen, 2014-01-17)
Cis-regulatory elements can control gene transcription over large distances. Studying the association between cis-regulatory elements and the mechanism of gene regulation is important since the disruption in the transcriptional ...
The planetary biology of cytochrome P450 aromatases
(BioMed Central, 2004-08-17)
<p>Background: Joining a model for the molecular evolution of a protein family to the paleontological and geological records (geobiology), and then to the chemical structures of substrates, products, and protein folds, is ...
Cloning, expression and purification of Atlantic salmon (Salmo salar, L.) neuroglobin
(Elsevier Inc., 2012)
Neuroglobin (Ngb) exists only in small amounts in salmon brain. In order to study the protein in more detail salmon neuroglobin (sNgb) was cloned, hetereologously expressed in E.coli and purified. The protein had red ...
Histone complement of a rapidly evolving chordate Oikopleura dioica: Developmental and sex-specific deployment of novel and universal histone variants and their posttranslational modifications
(The University of Bergen, 2010-10-22)
The packaging of DNA into nucleosomes is a fundamentally conserved property of the eukaryotic nucleus which is evident in the conservation of histone sequences. Nevertheless, it is now clear that histone sequence variants ...
Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas
(Elsevier Science Ltd., 1999)
Using immunohistochemistry, expression of p53, transforming growth factor-alpha (TGF-α), epidermal growth factor receptor (EGFR), c-erbB-2/neu and proliferating cell nuclear antigen (PCNA) was examined in 26 fresh frozen ...