Blar i Faculty of Medicine på forfatter "Madsen, Lise"

Viser treff 1-19 av 19

    • Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells 

      Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Peer reviewed; Journal article, 2012-03-27)
      Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ...

    • Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats 

      Dankel, Simon Nitter; Kalleklev, Tine-Lise; Tungland, siri Lunde; Stafsnes, Marit Hallvardsdotter; Bruheim, Per; Aloysius, Thomas Aquinas; Lindquist, Carine; SKORVE, JON; Nygård, Ottar Kjell; Madsen, Lise; Bjørndal, Bodil; Sydnes, Magne Olav; Berge, Rolf Kristian (Journal article; Peer reviewed, 2023)
      Altered hepatic mitochondrial fatty acid β-oxidation and associated tricarboxylic acid (TCA) cycle activity contributes to lifestyle-related diseases, and circulating biomarkers reflecting these changes could have disease ...

    • Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice 

      Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi; Meugnier, Emmanuelle; Battistoni, Brigitte Le Magueresse; Frøyland, Livar; Madsen, Lise; Jessen, Niels; Lund, Sten; Vidal, Hubert; Ruzzin, Jérôme (Peer reviewed; Journal article, 2011-09-23)
      Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ...

    • Commercially available kelp and seaweed products – valuable iodine source or risk of excess intake? 

      Aakre, Inger; Solli, Dina Doblaug; Markhus, Maria Wik; Mæhre, Hanne K; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Korneliussen, Patrick-Andre; Madsen, Lise; Kjellevold, Marian (Journal article; Peer reviewed, 2021)
      Background: Seaweeds and kelps, also known as macroalgae, have long been common in the East-Asian diet. During recent years, macroalgae have entered the global food market, and a variety of macroalgae products are now ...

    • Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean 

      Ho, Quang Tri; Frantzen, Sylvia; Nilsen, Bente Merete; Nøstbakken, Ole Jakob; Mahjour Azad, Atabak; Duinker, Arne; Madsen, Lise; Bank, Michael (Journal article; Peer reviewed, 2023)
      Bioaccumulation of persistent organic pollutants (POPs) in marine fish may pose a health risk to human consumers. Using data from ∼8400 individuals of 15 fish species collected in the North-East Atlantic Ocean (NEAO), we ...

    • Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet 

      Alvheim, Anita Røyneberg; Torstensen, Bente Elisabeth; Lin, Yu Hong; Lillefosse, Haldis Haukås; Lock, Erik-Jan; Madsen, Lise; Frøyland, Livar; Hibbeln, Joseph R.; Malde, Marian Kjellevold (Peer reviewed; Journal article, 2014-01)
      Dietary intake of linoleic acid (LNA, 18:2n-6) has increased dramatically during the 20th century and is associated with greater prevalence of obesity. The endocannabinoid system is involved in regulation of energy balance ...

    • Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice 

      Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Rasinger, Josef; Lie, Kai Kristoffer; Bernhard, Annette; Madsen, Lise; Nøstbakken, Ole Jakob (Journal article; Peer reviewed, 2022-10-13)
      Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ...

    • Differences in nutrient and undesirable substance concentrations in Maurolicus muelleri across the Bay of Biscay, Norwegian fjords, and the North Sea 

      Zhu, Yiou; Mahjour Azad, Atabak; Kjellevold, Marian; Bald, Carlos; Iñarra, Bruno; Alvarez, Paula; Boyra, Guillermo; Berntssen, Marc HG; Madsen, Lise; Wiech, Martin (Journal article; Peer reviewed, 2023)
      Introduction: We are having pressing issues of global food insecurity and malnutrition. Mesopelagic communities in the North Atlantic have been estimated to have high biomasses of organisms. Some of these low-trophic ...

    • Effects of Frozen Storage on Phospholipid Content in Atlantic Cod Fillets and the Influence on Diet-Induced Obesity in Mice 

      Fauske, Kristin Røen; Bernhard, Annette; Fjære, Even; Myrmel, Lene Secher; Frøyland, Livar; Kristiansen, Karsten; Liaset, Bjørn; Madsen, Lise (Peer reviewed; Journal article, 2018-05-30)
      A large fraction of the n-3 polyunsaturated fatty acids (PUFAs) in cod fillet is present in the form of phospholipids (PLs). Freezing initiates hydrolysis of the PLs present in the fillet. Here, we compared the effects of ...

    • The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice 

      Myrmel, Lene Secher; Fauske, Kristin Røen; Fjære, Even; Bernhard, Annette; Liisberg, Ulrike; Hasselberg, Astrid Elise; Øyen, Jannike; Kristiansen, Karsten; Madsen, Lise (Peer reviewed; Journal article, 2019-05-23)
      Low-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and ...

    • Increased microvascular permeability in mice lacking Epac1 (Rapgef3) 

      Kopperud, Reidun Kristin; Rygh, Cecilie Brekke; Karlsen, Tine Veronica; Krakstad, Camilla; Kleppe, Rune; Høivik, Erling Andre; Bakke, Marit; Tenstad, Olav; Selheim, Frode; Liden, Åsa; Madsen, Lise; Pavlin, Tina; Taxt, Torfinn; Kristiansen, K.; Curry, FE; Reed, Rolf K.; Doskeland, Stein Ove (Peer reviewed; Journal article, 2017-02)
      Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ...

    • Iodine status and thyroid function in a group of seaweed consumers in Norway 

      Aakre, Inger; Evensen, Lidunn Tveito; Kjellevold, Marian; Dahl, Lisbeth; Henjum, Sigrun; Alexander, Jan; Madsen, Lise; Markhus, Maria Wik (Journal article; Peer reviewed, 2020)
      Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. ...

    • Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity 

      Mahjour Azad, Atabak; Bernhard, Annette; Shen, Anne; Myrmel, Lene Secher; Lundebye, Anne-Katrine; Lecaudey, Laurene Alicia; Fjære, Even; Ho, Quang Tri; Sveier, Harald; Kristiansen, Karsten; Limborg, Morten Tønsberg; Madsen, Lise (Journal article; Peer reviewed, 2023)
      Alternative feed ingredients for farmed salmon are warranted due to increasing pressure on wild fish stocks. As locally farmed blue mussels may represent an environmentally sustainable substitute with a lower carbon ...

    • One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects 

      Ersland, Kari Merete; Myrmel, Lene Secher; Fjære, Even; Berge, Rolf Kristian; Madsen, Lise; Steen, Vidar Martin; Skrede, Silje (Peer reviewed; Journal article, 2019-05)
      Background: Antipsychotic drugs can negatively affect the metabolic status of patients, with olanzapine as one of the most potent drugs. While patients are often medicated for long time periods, experiments in rats typically ...

    • Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats 

      Bjune, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon N; Berge, Rolf Kristian (Journal article; Peer reviewed, 2021)
      Objective: Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ...

    • RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice 

      Mellingen, Ragnhild Marie; Myrmel, Lene Secher; Lie, Kai Kristoffer; Rasinger, Josef; Madsen, Lise; Nøstbakken, Ole Jakob (Journal article; Peer reviewed, 2021)
      Methylmercury (MeHg) is a highly neurotoxic form of mercury (Hg) present in seafood. Here, we recorded and compared proteomic and transcriptomic changes in hippocampus of male BALB/c mice exposed to two doses of MeHg. Mice ...

    • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance 

      Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona Synnøve; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)
      Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...

    • Temporal variations in the nutrient content of Norwegian farmed Atlantic salmon (Salmo salar), 2005–2020 

      Reksten, Amalie Moxness; Ho, Quang Tri; Nøstbakken, Ole Jakob; Markhus, Maria Wik; Kjellevold, Marian; Bøkevoll, Annbjørg; Hannisdal, Rita; Frøyland, Livar; Madsen, Lise; Dahl, Lisbeth (Journal article; Peer reviewed, 2022)
      The changes in the feed of farmed Atlantic salmon (Salmo salar) towards a more plant-based diet affect the nutritional value of the fillets. By compiling the contents of a range of nutrients in 1108 samples of Norwegian ...

    • UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity 

      Madsen, Lise; Pedersen, Lone M.; Lillefosse, Haldis Haukaas; Fjære, Even; Brønstad, Ingeborg; Hao, Qin; Petersen, Rasmus Koefoed; Hallenborg, Philip; Ma, Tao; De Matteis, Rita; Araujo, Pedro; Mercader, Josep; Bonet, M. Luisa; Hansen, Jacob B.; Cannon, Barbara; Nedergaard, Jan; Wang, Jun; Cinti, Saverio; Voshol, Peter; Døskeland, Stein Ove; Kristiansen, Karsten (Peer reviewed; Journal article, 2010-06-30)
      Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ...