Blar i Faculty of Medicine på emneord "Mutation"
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Effekt av baseutkuttingsreparasjon på 5-formyluracil-indusert mutagenese
(Master thesis, 2010-11-30)5-Formyluracil (fU) is an oxidation derivate of the DNA-base thymine. It can emerge in the organism by attack of reactive oxygen species, either endogenously or exogenously. Examples of exogenous agents are irradiaton or ... -
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
(Peer reviewed; Journal article, 2012)BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ... -
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
(Peer reviewed; Journal article, 2018-06-25)Background: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific ...