• Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections 

      Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)
      Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ...
    • CD64 as a potential biomarker in septic arthritis 

      Oppegaard, Oddvar; Skodvin, Brita; Halse, Anne-Kristine; Langeland, Nina (Peer reviewed; Journal article, 2013-06-19)
      Background Traditional inflammatory markers are generally unhelpful in discerning septic arthritis from inflammatory joint disease due to their lack of specificity. We wished to explore the discriminatory power of the novel ...
    • Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors 

      Bruun, Trond; Oppegaard, Oddvar; Hufthammer, Karl Ove; Langeland, Nina; Skrede, Steinar (Peer reviewed; Journal article, 2016)
      Background: Skin and soft tissue infections are common reasons for medical care. Use of broad-spectrum therapy and costs have increased. Assessment of early treatment response has been given a central role both in clinical ...
    • Emergence of a Streptococcus dysgalactiae subspecies equisimilis stG62647-lineage associated with severe clinical manifestations 

      Oppegaard, Oddvar; Mylvaganam, Haima; Skrede, Steinar; Lindemann, Paul Christoffer; Kittang, Bård Reiakvam (Peer reviewed; Journal article, 2017-08-08)
      Increasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (SDSE) infections have been reported worldwide, but the evolutionary mechanisms underlying this development remain elusive. Through ...
    • Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018 

      Kaci, Alba; Jonassen, Christine M; Skrede, Steinar; Sivertsen, Audun; Steinbakk, Martin; Oppegaard, Oddvar (Journal article; Peer reviewed, 2023)
      Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ...
    • Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections 

      Siemens, Nikolai; Kittang, Bård Reiakvam; Chakrakodi, Bhavya; Oppegaard, Oddvar; Johansson, Linda; Bruun, Trond; Mylvaganam, Haima; Svensson, Mattias; Skrede, Steinar; Norrby-Teglund, Anna (Peer reviewed; Journal article, 2015)
      Streptococcus dysgalactiae subsp. equisimilis (SDSE) has emerged as an important cause of severe skin and soft tissue infections, but little is known of the pathogenic mechanisms underlying tissue pathology. Patient samples ...
    • A new pathway for penicillin delabeling in Norway 

      Alnæs, Marie Bjørbak; Oppegaard, Oddvar; Kittang, Bård Reiakvam; Lygre, Stein Håkon Låstad; Langeland, Anine Bernhoft; Skodvin, Brita; Bjånes, Tormod Karlsen; Storaas, Torgeir (Journal article; Peer reviewed, 2023)
      Background: Penicillin allergy is self-reported by 3–10% of patients admitted to hospital. The label is wrong in 90% of the cases and has severe health implications. Penicillin-delabeling can reverse the negative effects ...
    • Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway 

      Oppegaard, Oddvar; Skrede, Steinar; Mylvaganam, Haima; Kittang, Bård Reiakvam (Peer reviewed; Journal article, 2016-10-04)
      Background: Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished ...