Blar i Faculty of Medicine på emneord "Sjögren’s syndrome"
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Epidemiology of Sjögrens syndrome-from an oral perspective
(Peer reviewed; Journal article, 2016)Oral symptoms are among the most distressing manifestations for patients with Sjögren’s syndrome (SS). The feeling of dry mouth is unpleasant, and hyposalivation may contribute to difficulty in speaking, chewing and ... -
Heat shock proteins and chronic fatigue in primary Sjögren's syndrome
(Peer reviewed; Journal article, 2016)Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system ... -
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2013-09-09)Introduction: Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the ... -
Lymphotoxin-beta Receptor blockade reduces CXCL13 in Lacrimal Glands and improves Corneal integrity in the NOD Model of Sjögren's Syndrome
(Peer reviewed; Journal article, 2011-11-01)Introduction: In Sjögren’s syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular ... -
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
(Peer reviewed; Journal article, 2019-07-31)Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of primary Sjögren’s syndrome (pSS). Non-SS sicca ... -
Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2019-02-21)Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ...