Recent Submissions

  • Patterns of transmitted HIV drug resistance in Europe vary by risk group 

    Frentz, Dineke; van de Vijver, David A.; Abecasis, Ana B.; Albert, Jan; Hamouda, Osamah; Jørgensen, Louise B.; Kücherer, Claudia; Struck, Daniel; Schmit, Jean-Claude; Vercauteren, Jürgen; Åsjø, Birgitta; Balotta, Claudia; Bergin, Colm; Beshkov, Danail; Camacho, Ricardo; Clotet, Bonaventura; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios; Linka, Kirsi Litsola Marek; Nielsen, Claus; Otelea, Dan; Paraskevis, Dimitrios; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne-Mieke; Boucher, Charles A.B.; Wensing, Annemarie (PLoS, 2014-04-10)
    Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
  • The link between periodontal disease and rheumatoid arthritis: An updated review 

    Koziel, Joanna; Mydel, Piotr Mateusz; Potempa, Jan (Springer, 2014-01)
    Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a ...
  • Proteomic analysis of total cellular proteins of human neutrophils 

    Tomazella, Gisele G.; da Silva, Idalete; Laure, Helen J.; Rosa, José C.; Chammas, Roger; Wiker, Harald G.; de Souza, Gustavo A.; Greene, Lewis J. (BioMed Central, 2009-08-31)
    Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...
  • Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach 

    Paraskevis, Dimitrios; Pybus, Oliver; Magiorkinis, Gkikas; Hatzakis, Angelos; Wensing, Annemarie M. J.; van de Vijver, David A.; Albert, Jan; Angarano, Guiseppe; Åsjø, Birgitta; Balotta, Claudia; Boeri, Enzo; Camacho, Ricardo; Chaix, Marie-Laure; Coughlan, Suzie; Costagliola, Dominique; De Luca, Andrea; de Mendoza, Carmen; Derdelinckx, Inge; Grossman, Zehava; Hamouda, Osama; Hoepelman, I. M.; Horban, Andrzej; Korn, Klaus; Kücherer, Claudia; Leitner, Thomas; Loveday, Clive; MacRae, Eilidh; Maljkovic-Berry, I.; Meyer, Laurence; Nielsen, Claus; Op de Coul, Eline L. M.; Ormaasen, Vidar; Perrin, Luc; Puchhammer-Stöckl, Elisabeth; Ruiz, Lidia; Salminen, Mika O.; Schmit, Jean-Claude; Schuurman, Rob; Soriano, Vincent; Stanczak, J.; Stanojevic, Maja; Struck, Daniel; Van Laethem, Kristel; Violin, M.; Yerly, Sabine; Zazzi, Maurizio; Boucher, Charles A.; Vandamme, Anne-Mieke; the SPREAD Programme (BioMed Central, 2009-05-20)
    Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from ...
  • The HELLP syndrome: clinical issues and management. A Review 

    Haram, Kjell; Svendsen, Einar; Abildgaard, Ulrich (The University of Bergen, 2009-02-26)
    Background: The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10–20% of cases with ...
  • Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren's syndrome in salivary glands of non-obese diabetic mice 

    Gatumu, Margaret Karimi; Skarstein, Kathrine; Papandile, Adrian; Browning, Jeffrey L.; Fava, Roy A.; Bolstad, Anne Isine (BioMed Central, 2009-02-18)
    Introduction The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases ...
  • Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation 

    Olsnes, Carla; Stavang, Helen Åse Margrethe; Brokstad, Karl Albert; Olofsson, Jan; Aarstad, Hans Jørgen (BioMed Central, 2009-01-28)
    Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the ...
  • Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas 

    Bachmann, Ingeborg M.; Ladstein, Rita Grude; Straume, Oddbjørn; Naumov, George N.; Akslen, Lars A. (BioMed Central, 2008-12-05)
    Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ...
  • Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia 

    Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem; Stordrange, Laila; Jonassen, Inge; Bruserud, Øystein; Kalland, Karl-Henning; Gjertsen, Bjørn Tore (BioMed Central, 2009-03-05)
    Background: The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect ...
  • Effect of Ascaris Lumbricoides specific IgE ontuberculin skin test responses in children in a high-burdensetting: a cross-sectional community-based study 

    van Soelen, Nelda; Mandalakas, Anna M; Kirchner, H Lester; Walzl, Gerhard; Grewal, Harleen M. S.; Jacobsen, Marc; Hesseling, Anneke C. (BioMed Central, 2012-09-11)
    Background: M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate ...
  • A high confidence, manually validated human blood plasma protein reference set 

    Schenk, Susann; Schoenhals, Gary J.; De Souza, Gustavo A.; Mann, Matthias (BioMed Central, 2008-09-15)
    Background: The immense diagnostic potential of human plasma has prompted great interest and effort in cataloging its contents, exemplified by the Human Proteome Organization (HUPO) Plasma Proteome Project (PPP) pilot ...
  • Biological Characteristics of Stem-Like Cells in Oral Squamous Cell Carcinoma 

    Liang, Xiao (The University of Bergen, 2013-06-18)
    It has been shown that many solid malignancies, including oral squamous cell carcinoma (OSCC), contain a small population of tumorigenic cells referred to as cancer stem-like cells (CSCs) or tumor initiating cells (TICs). ...
  • Generation of a stepwise prostate carcinogenesis model. A study of epithelial to mesenchymal transition and malignant transformation of prostate primary epithelial cells 

    Qu, Yi (The University of Bergen, 2013-05-29)
    Despite progress in recent years, prostate cancer continues to be one of the most prevalent causes of cancer-related mortality and morbidity in men in Western countries. A major clinical challenge of prostate cancer ...
  • Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation 

    Ke, Xi-Song; Qu, Yi; Goldfinger, Naomi; Rostad, Kari; Hovland, Randi; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Public Library of Science, 2008-10-13)
    Background: Epithelial to mesenchymal transition (EMT) has been connected with cancer progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has been induced in prostate cancer cell ...
  • Lipocalin 2 expression is associated with aggressive features of endometrial cancer 

    Mannelqvist, Monica; Stefansson, Ingunn; Wik, Elisabeth; Kusonmano, Kanthida; Ræder, Maria B.; Øyan, Anne Margrete; Kalland, Karl-Henning; Moses, Marsha A.; Salvesen, Helga B.; Akslen, Lars A. (BioMed Central, 2012-05-06)
    Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...
  • Expression of ESE-3 Isoforms in Immunogenic and Tolerogenic Human Monocyte-Derived Dendritic Cells 

    Sprater, Florian; Hovden, Arnt-Ove; Appel, Silke (Public Library of Science, 2012-11-19)
    Dendritic cells (DC) are the only hematopoietic cells expressing the epithelial specific Ets transcription factor ESE-3. Here we analyzed presence and quantity of isoforms ESE-3a, ESE-3b and ESE-3j in various immunogenic ...
  • The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner 

    Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke (Public Library of Science, 2012-02-21)
    Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ...
  • Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation 

    Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (BioMed Central Ltd., 2012-01-17)
    Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ...
  • Interactions between Fusobacterium nucleatum and Primary Human Oral Cells: In Vitro Studies in Monolayer and Organotypic Culture Models 

    Dabija-Wolter, Gabriela (The University of Bergen, 2012-06-21)
    F. nucleatum is a Gram-negative bacterium, member of normal flora in the oral cavity, which has a major role in the formation of the subgingival biofilm. The adhesins expressed on the cell wall outer membrane confer F. ...
  • Secreted proteins of mycobacteria and their role during infection 

    Leversen, Nils Anders (The University of Bergen, 2012-03-23)
    One-third of the world’s population is infected with the causative agent of tuberculosis, Mycobacterium tuberculosis. A fraction of infected individuals have an active form of the disease, while the remainder is able to ...

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