Blar i Department of Biomedicine på tittel

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    • Activated NK cells are potent effectors against glioblastoma cells due to activating KIR2DS2 and KIR2DS4 - HLA ligand interactions - In vitro study 

      Gras Navarro, Andrea (Master thesis, 2013-06-03)
      Background: Glioblastoma (GBM) is the most malignant brain tumor, where patients' median survival is only 14,6 months after diagnosis, thus novel, effective adjuvant therapies are required. Natural Killer (NK) cells are ...

    • Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells 

      Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Peer reviewed; Journal article, 2012-03-27)
      Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ...

    • Activation-induced chromatin reorganization in neurons depends on HDAC1 activity 

      Grabowska, Agnieszka; Sas-Nowosielska, Hanna; Wojtas, Bartosz; Holm-Kaczmarek, Dagmara; Januszewicz, Elzbieta; Yushkevich, Yana; Czaban, Iwona; Trzaskoma, Pawel; Krawczyk, Katarzyna; Gielniewski, Bartlomiej; Martin-Gonzalez, Ana; Filipkowski, Robert Kuba; Olszynski, Krzysztof Hubert; Bernas, Tytus; Szczepankiewicz, Andrzej Antoni; Sliwinska, Malgorzata Alicja; Kanhema, Tambudzai; Bramham, Clive Raymond Evjen; Bokota, Grzegorz; Plewczynski, Dariusz; Wilczynski, Grzegorz Marek; Magalska, Adriana (Journal article; Peer reviewed, 2022)
      Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ...

    • Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators 

      Bustad, Helene J.; Kallio, Juha Pekka; Vorland, Marta; Fiorentino, Valeria; Sandberg, Sverre; Schmitt, Caroline; Aarsand, Aasne Karine; Martinez, Aurora (Journal article; Peer reviewed, 2021)
      Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) gene, which encodes the third enzyme in the haem ...

    • ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications 

      Homaei, Selina Cannon; Barone, Helene; Kleppe, Rune; Betari, Nibal; Reif, Andreas; Haavik, Jan (Journal article; Peer reviewed, 2021)
      Neurometabolic diseases (NMDs) are typically caused by genetic abnormalities affecting enzyme functions, which in turn interfere with normal development and activity of the nervous system. Although the individual disorders ...

    • ADP-ribosyltransferases, an update on function and nomenclature 

      Lüscher, Bernhard; Ahel, I; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael S.; Corda, Daniela; Dantzer, F.; Daugherty, MD; Dawson, TM; Dawson, VL; Deindl, S; Fehr, AR; Feijs, KLH; Filippov, DV; Gagné, JP; Grimaldi, Giulia; Guettler, S; Hoch, NC; Hottiger, MO; Korn, P; Kraus, WL; Ladurner, Andreas G.; Lehtiö, Lari; Leung, AKL; Lord, CJ; Mangerich, A; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L.; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M; Pawłowski, Krzysztof; Poirier, Guy G; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yélamos, José; Xiaochun, Yu; Zaja, Roko; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- ...

    • Adult ADHD and Comorbid Somatic Disease: A Systematic Literature Review 

      Instanes, Johanne Telnes; Klungsøyr, Kari; Halmøy, Anne; Fasmer, Ole Bernt; Haavik, Jan (Peer reviewed; Journal article, 2016)
      Objective: To systematically review, synthesize, and appraise available evidence, connecting adult ADHD (aADHD) with somatic disease. Method: Embase, Psychinfo, and Medline databases were searched for studies published ...

    • Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients 

      Tysnes, Berit Bølge; Sætran, Hege Aase; Mørk, Sverre; Margaryan, Naira v.; Eide, Geir Egil; Petersen, Kjell; Strizzi, Luigi; Hendrix, J. C. (Peer reviewed; Journal article, 2013-12)
      Exploring the re-emergence of embryonic signaling pathways may reveal important information for cancer biology. Nodal is a transforming growth factor-β (TGF-β)-related morphogen that plays a critical role during embryonic ...

    • Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors 

      Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. (Peer reviewed; Journal article, 2014-06-26)
      Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to ...

    • AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy 

      Zandt, Bas-Jan; Liu, Jian Hao; Veruki, Margaret Lin; Hartveit, Espen (Peer reviewed; Journal article, 2016-02)
      AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a ...

    • Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease 

      Bjånesøy, Trine Elholm; Andreassen, Bettina Kulle; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit (Peer reviewed; Journal article, 2014-03-22)
      Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...

    • Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...

    • AMPA receptors at ribbon synapses in the mammalian retina: kinetic models and molecular identity 

      Hartveit, Espen; Zandt, Bas-Jan; Madsen, Eirik; Castilho, Aurea; Mørkve, Svein Harald; Veruki, Margaret Lin (Peer reviewed; Journal article, 2018)
      In chemical synapses, neurotransmitter molecules released from presynaptic vesicles activate populations of postsynaptic receptors that vary in functional properties depending on their subunit composition. Differential ...

    • Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer 

      Tabach, Yuval; Kogan-Sakin, Ira; Buganim, Yosef; Solomon, Hilla; Goldfinger, Naomi; Hovland, Randi; Ke, Xi-Song; Øyan, Anne Margrete; Kalland, Karl-Henning; Rotter, Varda; Domany, Eytan (Peer reviewed; Journal article, 2011-01-31)
      Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ...

    • AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion 

      Schuster, Anne; Klein, Eliane; Neirinckx, Virginie; Møldrup Knudsen, Arnon; Fabian, Carina; Hau, Ann-Christin; Dieterle, Monika; Oudin, Anaïs; Nazarov, Petr V.; Golebiewska, Anna; Muller, Arnaud; Perez-Hernandez, Daniel; Rhodius, Sophie; Dittmar, Gunnar; Bjerkvig, Rolf; Herold-Mende, Christel; Klink, Barbara; Winther Kristensen, Bjarne; Niclou, Simone Pierrette (Journal article; Peer reviewed, 2020)
      The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic ...

    • Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria 

      Jokela, Jouni; Oftedal, Linn; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2012-07-19)
      Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...

    • Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B 

      Pires, Isa; Hung, Yu-Fu; Bergmann, Ulrich; Molloy, Justin E.; Kursula, Inari (Journal article; Peer reviewed, 2022)
      Myosin B (MyoB) is a class 14 myosin expressed in all invasive stages of the malaria parasite, Plasmodium falciparum. It is not associated with the glideosome complex that drives motility and invasion of host cells. During ...

    • Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets 

      Postema, Merel C.; Hoogman, Martine; Ambrosino, Sara; Asherson, Philip; Banaschewski, Tobias; Bandeira, Cibele E.; Baranov, Alexandr; Bau, Claiton H.D.; Baumeister, Sarah; Baur-Streubel, Ramona; Bellgrove, Mark A.; Biederman, Joseph; Bralten, Janita; Brandeis, Daniel; Brem, Silvia; Buitelaar, Jan K.; Busatto, Geraldo F.; Castellanos, Francisco X.; Cercignani, Mara; Chaim-Avancini, Tiffany M.; Chantiluke, Kaylita C.; Christakou, Anastasia; Coghill, David; Conzelmann, Annette; Cubillo, Ana; Cupertino, Renata B.; de Zeeuw, Patrick; Doyle, Alysa E.; Durston, Sarah; Earl, Eric A.; Epstein, Jeffery N.; Ethofer, Thomas; Fair, Damien A.; Fallgatter, Andreas J.; Faraone, Stephen V.; Frodl, Thomas; Gabel, Matt C.; Gogberashvili, Tinatin; Grevet, Eugenio H.; Haavik, Jan; Harrison, Neil A.; Hartman, Catharina A.; Heslenfeld, Dirk J.; Hoekstra, Pieter J.; Hohmann, Sarah; Høvik, Marie Farstad; Jernigan, Terry L.; Kardatzki, Bernd; Karkashadze, George A.; Kelly, Clare; Kohls, Gregor; Konrad, Kerstin; Kuntsi, Jonna; Lazaro, Luisa; Lera-Miguel, Sara; Lesch, Klaus-Peter; Louza, Mario R.; Lundervold, Astri J.; Malpas, Charles B.; Mattos, Paulo; McCarthy, Hazel; Namazova-Baranova, Leyla; Nicolau, Rosa; Nigg, Joel T.; Novotny, Stephanie E.; Oberwelland Weiss, Eileen; O'Gorman Tuura, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Paloyelis, Yannis; Pauli, Paul; Picon, Felipe A.; Plessen, Kerstin J.; Ramos-Quiroga, J. Antoni; Reif, Andreas; Reneman, Liesbeth; Rosa, Pedro G.P.; Rubia, Katya; Schrantee, Anouk; Schweren, Lizanne J.S.; Seitz, Jochen; Shaw, Philip; Silk, Tim J.; Skokauskas, Norbert; Soliva, Joan Carles; Stevens, Michael C.; Sudre, Gustavo; Tamm, Leanne; Tovar-Moll, Fernanda; van Erp, Theo G.M.; Vance, Alasdair; Vilarroya, Oscar; Vives-Gilabert, Yolanda; von Polier, Georg G.; Walitza, Susanne; Yoncheva, Yuliya N.; Zanetti, Marcus V; Ziegler, Georg C.; Glahn, David C.; Jahanshad, Neda; Medland, Sarah E.; Thompson, Paul M.; Fisher, Simon E.; Franke, Barbara; Francks, Clyde (Journal article; Peer reviewed, 2021)
      Objective Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the ...

    • Analyzing the Structure of Pathways and Its Influence on the Interpretation of Biomedical Proteomics Data Sets 

      Burger, Bram; Hernández Sánchez, Luis Francisco; Lereim, Ragnhild Reehorst; Barsnes, Harald; Vaudel, Marc (Peer reviewed; Journal article, 2018)
      Biochemical pathways are commonly used as a reference to conduct functional analysis on biomedical omics data sets, where experimental results are mapped to knowledgebases comprising known molecular interactions collected ...

    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...