Now showing items 61-70 of 189
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia
Congenital tyrosine hydroxylase deficiency (THD) is found in autosomal-recessive Dopa-responsive dystonia and related neurological syndromes. The clinical manifestations of THD are variable, ranging from early-onset lethal ...
Design of tumour-specific immunotherapies using dendritic cells – analyses of IL15-DC
(The University of Bergen, 2009-05-31)
Immunotherapy of malignancies aims at activating the patient’s own immune system to fight the tumour affecting the patient. Even though the use of dendritic cells (DC) has shown promising results, the DC vaccination strategy ...
Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties
Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ...
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(The University of Bergen, 2012-05-30)
Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ...
Novel Points of Attack for Targeted Cancer Therapy
(WileyNordic Pharmacological Society, 2015-01)
New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
Chronic mild stress - an anmial model of depression : from behavior to molecules
(The University of Bergen, 2006-11-03)
Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease
Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...
The Heart and a Fibrotic Interstitium
(The University of Bergen, 2009-05-29)
Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ...
Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains
(BioMed Central, 2011-01-24)
Background: The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study ...
Development of an RNA Interference Tool, Characterization of Its Target, and an Ecological Test of Caste Differentiation in the Eusocial Wasp Polistes
(Public Library of Science, 2011-11-01)
Recent advancements in genomics provide new tools for evolutionary ecological research. The paper wasp genus Polistes is a model for social insect evolution and behavioral ecology. We developed RNA interference (RNAi)-mediated ...