Now showing items 1-20 of 188

  • Experimental modeling and novel therapeutic strategies in melanoma brain metastasis 

    Sundstrøm, Terje (The University of Bergen, 2015-06-09)
    Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ...
    Doctoral thesis
  • Voxel dimension optimization for probabilistic tractography in rat brain using 7T scanner 

    Kurzawski, Jan Wirgiliusz (The University of Bergen, 2015-06-01)
    Brain connectivity is an increasingly important research field within neuroscience. Using MRI technology it is now possible to measure diffusion to approximate the location of anatomical tracts in the brain or correlate ...
    Master thesis
  • Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia 

    Hinrichs, Carina (The University of Bergen, 2015-06-01)
    An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ...
    Master thesis
  • Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass 

    Dahle, Geir Olav; Salminen, Pirjo-Riitta; Moen, Christian Arvei; Eliassen, Finn; Jonassen, Anne K.; Haaverstad, Rune; Matre, Knut; Grong, Ketil (Elsevier, 2015-06)
    Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ...
    Journal article
  • EEG Analysis in Adults with Attention-Deficit-Hyperactivity-Disorder. Resting state and behavioural data analysis 

    Marquardt, Lynn Anne (The University of Bergen, 2015-05-31)
    Introduction: Adults with attention-deficit/hyperactivity disorder (ADHD) are examined by electroencephalography (EEG). EEG is a non-invasive method to measure brain activity indirectly, by measuring voltage changes on the ...
    Master thesis
  • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

    Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
    Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
    Journal article
  • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

    Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    Journal article
  • Novel Points of Attack for Targeted Cancer Therapy 

    Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tenfjord (WileyNordic Pharmacological Society, 2015-01)
    New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
    Journal article
  • A three dimensional visualisation approach to protein heavy-atom structure reconstruction 

    Peng, Xubiao; Chenani, Alireza; Hu, Shuangwei; Zhou, Yifan; Niemi, Antti J. (BioMed Central, 2014-12-31)
    Background: A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates. Results: We employ advances in virtual ...
    Journal article
  • A novel GFP nude rat model to investigate tumor-stroma interactions 

    Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-12-21)
    Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...
    Journal article
  • Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling 

    Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (BioMed Central, 2014-12-20)
    Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ...
    Journal article
  • Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma 

    Keunen, Olivier (The University of Bergen, 2014-12-18)
    Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...
    Doctoral thesis
  • Integrating protein structural dynamics and evolutionary analysis with Bio3D 

    Skjærven, Lars; Yao, Xin-Qiu; Scarabelli, Guido; Grant, Barry J. (BioMed Central, 2014-12-10)
    Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining how ...
    Journal article
  • Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

    Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga B.; Wiig, Helge; Tenstad, Olav (Elsevier, 2014-12)
    Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. Nevertheless, ...
    Journal article
  • Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. 

    Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; jacobsen, hk; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian (Elsevier, 2014-12)
    Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ...
    Journal article
  • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

    Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Cell Press, 2014-11-20)
    BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...
    Journal article
  • Post-translational modifications of integrin ligands as pathogenic mechanisms in disease 

    Zeltz, Cedric; Gullberg, Donald (Elsevier, 2014-11)
    Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational ...
    Journal article
  • Novel Points of Attack for Targeted Cancer Therapy 

    Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tennfjord (WileyNordic Association for the Publication of BCPT, 2014-10-30)
    New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
    Journal article
  • The laminin response in inflammatory bowel disease: Protection or malignancy? 

    Spenle, Caroline; Lefebvre, Olivier; Lacroute, Joel; Mechine-Neuville, Agnes; Barreau, Frederick; Blottiere, Herve M; Duclos, Bernard; Arnold, Christiane; Hussenet, Thomas; Hemmerle, Joseph; Gullberg, Donald; Kedinger, Michele; Sorokin, Lydia; Orend, Gertraud; Simon-Assmann, Patricia (PLoS, 2014-10-27)
    Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment ...
    Journal article
  • Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution 

    Helgeland, Erik; Breivik, Lars Ertesvåg; Vaudel, Marc; Svendsen, Øyvind Sverre; Garberg, Hilde Kristin; Nordrehaug, Jan Erik; Berven, Frode S.; Jonassen, Anne Kristin (PLoS, 2014-10-15)
    Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ...
    Journal article