BORA - UiB

Bergen Open Research Archive

Browsing Department of Biomedicine by Issue Date

Bergen Open Research Archive

Browsing Department of Biomedicine by Issue Date

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  • Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tenfjord (Journal article, WileyNordic Pharmacological Society, 2015-01)
    New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
  • Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Journal article, Springer, 2015-01)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
  • Peng, Xubiao; Chenani, Alireza; Hu, Shuangwei; Zhou, Yifan; Niemi, Antti J. (Journal article, BioMed Central, 2014-12-31)
    Background: A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates. Results: We employ advances ...
  • Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Journal article, BioMed Central, 2014-12-21)
    Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing ...
  • Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Journal article, BioMed Central, 2014-12-20)
    Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human ...
  • Keunen, Olivier (Doctoral thesis, The University of Bergen, 2014-12-18)
    Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...
  • Skjærven, Lars; Yao, Xin-Qiu; Scarabelli, Guido; Grant, Barry J. (Journal article, BioMed Central, 2014-12-10)
    Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining ...
  • Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga B.; Wiig, Helge; Tenstad, Olav (Journal article, Elsevier, 2014-12)
    Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ...
  • Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; jacobsen, hk; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian (Journal article, Elsevier, 2014-12)
    Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ...
  • Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Journal article, Cell Press, 2014-11-20)
    BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...
  • Zeltz, Cedric; Gullberg, Donald (Journal article, Elsevier, 2014-11)
    Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational ...
  • Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tennfjord (Journal article, WileyNordic Association for the Publication of BCPT, 2014-10-30)
    New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
  • Spenle, Caroline; Lefebvre, Olivier; Lacroute, Joel; Mechine-Neuville, Agnes; Barreau, Frederick; Blottiere, Herve M; Duclos, Bernard; Arnold, Christiane; Hussenet, Thomas; Hemmerle, Joseph; Gullberg, Donald; Kedinger, Michele; Sorokin, Lydia; Orend, Gertraud; Simon-Assmann, Patricia (Journal article, PLoS, 2014-10-27)
    Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment ...
  • Helgeland, Erik; Breivik, Lars Ertesvåg; Vaudel, Marc; Svendsen, Øyvind Sverre; Garberg, Hilde Kristin; Nordrehaug, Jan Erik; Berven, Frode S.; Jonassen, Anne Kristin (Journal article, PLoS, 2014-10-15)
    Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ...
  • Shrestha, Anjana (Doctoral thesis, The University of Bergen, 2014-10-10)
    Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation. Development of tooth results from ...
  • Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian (Journal article, BioMed Central, 2014-10-04)
    Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ...
  • Keunen, Olivier; Taxt, Torfinn; Grüner, Renate; Lund-Johansen, Morten; Tonn, Joerg-Christian; Pavlin, Tina; Bjerkvig, Rolf; Niclou, Simone P.; Thorsen, Frits Alan (Journal article, Elsevier, 2014-09-30)
    The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology remains ...
  • Brekke, Cecilie; Wang, Jian; Thuen, Marte; Gras Navarro, Andrea; Huuse-Røneid, Else Marie; Thorsen, Frits Alan; Poli, Aurélie; Zimmer, Jacques; Haraldseth, Olav; Lie, Stein Atle; Enger, Per Øyvind; Chekenya, Martha (Journal article, Public Library of Science, 2014-09-30)
    There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and ...
  • Zeltz, Cedric; Orgel, Joseph; Gullberg, Donald (Journal article, Elsevier, 2014-08)
    Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar ...
  • Lu, Ning; Karlsen, Tine Veronica; Reed, Rolf K.; Kusche-Gullberg, Marion; Gullberg, Donald (Journal article, PLoS, 2014-07-30)
    We have previously shown that fibroblast expression of α11β1 integrin stimulates A549 carcinoma cell growth in a xenograft tumor model. To understand the molecular mechanisms whereby a collagen receptor on fibroblast can ...

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