Now showing items 1-20 of 123

  • The 14-3-3 proteins in regulation of cellular metabolism 

    Kleppe, Rune; Martinez, Aurora; Doskeland, Stein Ove; Haavik, Jan (Elsevier, 2011-09)
    Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ...
  • Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells 

    Jia, Bingbing; Madsen, Lise; Petersen, Rasmus Koefoed; Techer, Nathalie; Kopperud, Reidun Kristin; Ma, Tao; Døskeland, Stein Ove; Ailhaud, Gérard; Wang, Jinfu; Amri, Ez-Zoubir; Kristiansen, Karsten (Public Library of Science, 2012-03-27)
    Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ...
  • Age-dependent association between protein expression of the embryonic stem cell marker Cripto-1 and survival of glioblastoma patients 

    Tysnes, Berit Bølge; Sætran, Hege Aase; Mørk, Sverre; Margaryan, Naira v.; Eide, Geir Egil; Petersen, Kjell; Strizzi, Luigi; Hendrix, J. C. (Elsevier, 2013-12)
    Exploring the re-emergence of embryonic signaling pathways may reveal important information for cancer biology. Nodal is a transforming growth factor-β (TGF-β)-related morphogen that plays a critical role during embryonic ...
  • Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors 

    Pelissier, Fanny; Garbe, James C.; Ananthanarayanan, Badriprasad; Miyano, Masaru; Lin, ChunHan; Jokela, Tiina; Kumar, Sanjay; Stampfer, Martha R.; Lorens, James; LaBarge, Mark A. (Elsevier, 2014-06-26)
    Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed ...
  • Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease 

    Bjånesøy, Trine Elholm; Andreassen, Bettina Kulle; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit (Elsevier, 2014-03-22)
    Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...
  • Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer 

    Tabach, Yuval; Kogan-Sakin, Ira; Buganim, Yosef; Solomon, Hilla; Goldfinger, Naomi; Hovland, Randi; Ke, Xi-Song; Øyan, Anne Margrete; Kalland, Karl-Henning; Rotter, Varda; Domany, Eytan (Public Library of Science, 2011-01-31)
    Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an ...
  • Anabaenolysins, Novel Cytolytic Lipopeptides from Benthic Anabaena Cyanobacteria 

    Jokela, Jouni; Oftedal, Linn; Herfindal, Lars; Permi, Perttu; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Public Library of Science, 2012-07-19)
    Two novel cyclic lipopeptides, anabaenolysin A and anabaenolysin B, were isolated from two benthic cyanobacterial strains of the genus Anabaena. This novel class of cyanobacterial lipopeptides has a general structure of a ...
  • The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity 

    Oftedal, Linn; Skjærven, Kaja H.; Coyne, Rosie T.; Edvardsen, Bente; Rohrlack, Thomas; Skulberg, Olav M.; Døskeland, Stein Ove; Herfindal, Lars (Springer, 2010-08-06)
    Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ...
  • The Arc of synaptic memory 

    Bramham, Clive R.; Alme, Maria N.; Bittins, Margarethe; Kuipers, Sjoukje D.; Nair, Rajeevkumar R.; Pai, Balagopal; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin (Springer, 2010)
    The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous ...
  • Attention Network Test in adults with ADHD - the impact of affective fluctuations 

    Lundervold, Astri Johansen; Adólfsdóttir, Steinunn; Halleland, Helene Barone; Halmøy, Anne; Plessen, Kerstin von; Haavik, Jan (BioMed Central, 2011-07-27)
    Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls ...
  • Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties 

    Nikolaisen, Julie; Nilsson, Linn Iren Hodneland; Pettersen, Ina Katrine Nitschke; Willems, Peter H. G. M.; Lorens, James B.; Koopman, Werner J. H.; Tronstad, Karl Johan (PLoS, 2014-07-02)
    Mitochondrial morphology and function are coupled in healthy cells, during pathological conditions and (adaptation to) endogenous and exogenous stress. In this sense mitochondrial shape can range from small globular ...
  • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

    Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
  • Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines 

    Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (BioMed Central, 2009-11-13)
    Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...
  • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies 

    Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Elsevier, 2007-11)
    Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...
  • Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum 

    Akaddar, Aziza; Doderer-Lang, Cécile; Marzahn, Melissa R.; Delalande, François; Mousli, Marc; Helle, Karen Blaauw; Dorsselaer, Alain; Aunis, Dominique; Dunn, Ben M.; Metz-Boutigue, Marie-Hélène; Candolfi, Ermanno (Springer, 2010-02-23)
    Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides ...
  • Cellular Host Responses to Gliomas 

    Najbauer, Joseph; Huszthy, Peter Csaba; Barish, Michael E.; Garcia, Elizabeth; Metz, Marianne Z.; Myers, Sarah M.; Gutova, Margarita; Frank, Richard T.; Miletic, Hrvoje; Kendall, Stephen E.; Glackin, Carlotta A.; Bjerkvig, Rolf; Aboody, Karen S. (Public Library of Science, 2012-04-23)
    Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular ...
  • Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice 

    Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi; Meugnier, Emmanuelle; Battistoni, Brigitte Le Magueresse; Frøyland, Livar; Madsen, Lise; Jessen, Niels; Lund, Sten; Vidal, Hubert; Ruzzin, Jérôme (Public Library of Science, 2011-09-23)
    Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ...
  • A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma 

    Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-10-04)
    Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ...
  • Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture 

    Rajcevic, Uros; Knol, Jaco C; Piersma, Sander; Bougnaud, Sébastien; Fack, Fred; Sundlisæter, Eirik; Søndenaa, Karl; Myklebust, Reidar; Pham, Thang V.; Niclou, Simone P.; Jiménez, Connie R. (BioMed Central, 2014-07-11)
    Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ...
  • Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains 

    Målen, Hiwa; De Souza, Gustavo A.; Pathak, Sharad; Søfteland, Tina; Wiker, Harald G. (BioMed Central, 2011-01-24)
    Background: The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study ...