• Arc interacts with the integral endoplasmic reticulum protein, calnexin 

      Myrum, Craig; Soule, Jonathan; Bittins, Margarethe; Cavagnini, Kyle; Goff, Kevin; Ziemek, Silje Karina; Eriksen, Maria Steene; Patil, Sudarshan; Szum, Adrian; Nair Raveendran, Rajeevkumar; Bramham, Clive R. (Peer reviewed; Journal article, 2017-09-20)
      Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ...
    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Peer reviewed; Journal article, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
    • Common variants in the ARC gene are not associated with cognitive abilities 

      Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Peer reviewed; Journal article, 2015-09-03)
      Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
    • Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo 

      Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R. (Peer reviewed; Journal article, 2017-05-10)
      Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ...
    • Implication of the APP gene in intellectual abilities 

      Myrum, Craig; Nikolaienko, Oleksii; Bramham, Clive R.; Haavik, Jan; Zayats, Tetyana (Peer reviewed; Journal article, 2017)
      Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the ...