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Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype
Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated ...
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(The University of Bergen, 2012-11-05)
Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ...
Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
(Public Library of Science, 2009-07-28)
Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-b ...
Tumor oxygenation - influence on mammary tumor growth, progression and response to chemotherapy
(The University of Bergen, 2011-04-28)
Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer.
<p>Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ...
Hyperbaric oxygen therapy and cancer—a review
(Springer Verlag, 2012-10-02)
Hypoxia is a critical hallmark of solid tumors and involves enhanced cell survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen (HBO) treatment has for centuries been used to improve or cure ...
The Arc of synaptic memory
The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous ...
Abrogation of Anthracycline and Ischemia-Reperfusion Induced Injury by Cell Signaling Modulators
(The University of Bergen, 2013-10-18)
Chemotherapy has a long history in cancer treatment, and the anthracycline used in Paper I and II are among the most effective anti-cancer drugs developed. Unfortunately, the use of anthracyclines is dose-restricted due ...
Influence of organ motion on conformal vs. intensity-modulated pelvic radiotherapy for prostate cancer
(BioMed Central, 2008-08-01)
Enhanced gene expression from retroviral vectors
(BioMed Central, 2008-02-25)
Background: Retroviruses are widely used to transfer genes to mammalian cells efficiently and stably. However, genetic elements required for high-level gene expression are incompatible with standard systems. The retroviral ...