Blar i Department of Global Public Health and Primary Care på forfatter "Ueland, Per Magne"
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450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy
Joubert, Bonnie R.; Håberg, Siri Eldevik; Nilsen, Roy Miodini; Wang, Xuting; Vollset, Stein Emil; Murphy, Susan K; Huang, Zhiqing; Hoyo, Cathrine; Midttun, Øivind; Cupul-Uicab, Lea A; Ueland, Per Magne; Wu, Michael C; Nystad, Wenche; Bell, Douglas A; Peddada, Shyamal D; London, Stephanie J (Peer reviewed; Journal article, 2012-10)Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple ... -
Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study
Arora, Nikhil; Strand, Tor A; Chandyo, Ram K; Elshorbagy, Amany; Shrestha, Laxman; Ueland, Per Magne; Ulak, Manjeswori; Schwinger, Catherine (Journal article; Peer reviewed, 2020)Cysteine is a semi-essential amino acid that has been positively associated with growth in children. However, transgenerational effects remain unclear. The aim of this analysis was to assess whether maternal plasma total ... -
Association of Plasma Total Cysteine and Anthropometric Status in 6–30 Months Old Indian Children
Schwinger, Catherine; Chowdhury, Ranadip; Sharma, Shakun; Bhandari, Nita; Taneja, Sunita; Ueland, Per Magne; Strand, Tor A (Journal article; Peer reviewed, 2020)High-quality protein has been associated with child growth; however, the role of the amino acid cysteine remains unclear. The aim was to measure the extent to which plasma total cysteine (tCys) concentration is associated ... -
Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children
Solvik, Beate Stokke; Øyen, Jannike; Kvestad, Ingrid; Markhus, Maria Wik; Ueland, Per Magne; McCann, Adrian; Strand, Tor Arne (Journal article; Peer reviewed, 2021)Background Biomarkers such as omega-3 (n–3) PUFAs, urinary iodine concentration (UIC), 1-methylhistidine (1-MH), and trimethylamine N-oxide (TMAO) have been associated with fish intake in observational studies, but data ... -
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival
Johansson, Mattias; Anouar, Fanidi; Muller, David C.; Bassett, Julie K.; Midttun, Øivind; Vollset, Stein Emil; Travis, Ruth C.; Palli, Domenico; Mattiello, Amalia; Sieri, Sabina; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Ljungberg, Börje; Hallmans, Göran; Weiderpass, Elisabete; Skeie, Guri; Gonzalez, Carlos A.; Dorronsoro, Miren; Peeters, Petra H.; Bueno-de-Mesquita, H. B(as).; Ros, Martine M.; Ruault, Marie-Christine Boutron; Fagherazzi, Guy; Clavel, Françoise; Sanchez, Maria-Jose; Gurrea, Aurelio Barricarte; Navarro, Carmen; Quirós, J. Ramón; Overvad, Kim; Tjønneland, Anne; Aleksandrova, Krassimira; Vineis, Paolo; Gunter, Marc J.; Kaaks, Rudolf; Giles, Graham; Relton, Caroline; Riboli, Elio; Boeing, Heiner; Ueland, Per Magne; Severi, Gianluca; Brennan, Paul (Peer reviewed; Journal article, 2014)Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The ... -
Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal
Schwinger, Catherine; Sharma, Shakun; Chandyo, Ram K; Hysing, Mari; Kvestad, Ingrid; Ulak, Manjeswori; Ranjitkar, Suman; Shrestha, Merina; Shrestha, Laxman; McCann, Adrian; Ueland, Per Magne; Strand, Tor Arne (Journal article; Peer reviewed, 2021)The demand for cobalamin (vitamin B12) and folate is increased during pregnancy, and deficiency during pregnancy may lead to complications and adverse outcomes. Yet, the status of these micronutrients is unknown in many ... -
Dietary Intake and Biomarkers of Folate and Cobalamin Status in Norwegian Preschool Children: The FINS-KIDS Study
Solvik, Beate Stokke; Strand, Tor A; Kvestad, Ingrid; Markhus, Maria Wik; Ueland, Per Magne; McCann, Adrian; Øyen, Jannike (Journal article; Peer reviewed, 2020)Background: Folate and cobalamin (vitamin B-12) are essential for growth and development. However, few populationbased studies have investigated B-vitamin status in children. Objectives: This study aimed to assess biomarkers ... -
Dietary predictors of plasma total homocysteine concentration in the Hordaland Homocysteine Study
Konstantinova, Svetlana V.; Vollset, Stein Emil; Berstad, Paula; Ueland, Per Magne; Drevon, Christian A.; Refsum, Helga; Tell, Grethe Seppola (Peer reviewed; Journal article, 2007)Established dietary predictors of plasma total homocysteine (tHcy) include folate, riboflavin, and vitamins B6 and B12, while information is scarce regarding other dietary components. The aim of this study was to examine ... -
Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study
Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Midttun, Øyvind; Ulvik, Arve; Eide, Geir Egil; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-04-24)The risk of osteoporosis increases in inflammatory disorders. In cell-mediated immune activation, interferon (IFN)-γ stimulates macrophage release of neopterin and increases the activity of indoleamine 2,3-dioxygenase ... -
Interferon gamma (IFN-γ)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: The Hordaland Health Study
Apalset, Ellen M.; Gjesdal, Clara Gram; Ueland, Per Magne; Øyen, Jannike; Meyer, Klaus; Midttun, Øivind; Eide, Geir Egil; Tell, Grethe Seppola (Peer reviewed; Journal article, 2014-05-10)Summary The cytokine interferon gamma (IFN-γ) stimulates neopterin release and tryptophan degradation into kynurenines through the kynurenine pathway. High levels of neopterin were associated with increased hip fracture ... -
Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study
Zuo, Hui; Tell, Grethe Seppola; Vollset, Stein Emil; Ueland, Per Magne; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve; Eussen, Simone (Peer reviewed; Journal article, 2014-06-19)Background It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor ... -
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
Haugen, Johanne; Ulak, Manjeswori; Chandyo, Ram Krishna; Henjum, Sigrun; Thorne-Lyman, Andrew; Ueland, Per Magne; Midtun, Øivind; Shrestha, Prakash Sunder; Strand, Tor A (Peer reviewed; Journal article, 2016-12-21)Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy ... -
Markers of vitamin B6 status and metabolism as predictors of incident cancer: The Hordaland Health Study.
Zuo, Hui; Ueland, Per Magne; Eussen, Simone; Tell, Grethe Seppola; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2014-11-26)Dietary intake and/or circulating concentrations of vitamin B6 have been associated with risk of cancer, but results are inconsistent and mechanisms uncertain. Pyridoxal 5'-phosphate (PLP) is the most commonly used marker ... -
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
Joubert, Bonnie R; Den Dekker, Herman T; Felix, Janine F; Bohlin, Jon; Ligthart, Symen; Beckett, Emma; Tiemeier, Henning; van Meurs, Joyce B; Uitterlinden, Andre G; Hofman, Albert; Håberg, Siri Eldevik; Reese, Sarah E; Peters, Marjolein J; Kulle Andreassen, Bettina; Steegers, Eric A P; Nilsen, Roy Miodini; Vollset, Stein Emil; Midttun, Øivind; Ueland, Per Magne; Franco, Oscar H; Dehghan, Abbas; De Jongste, Johan C; Wu, Michael C; Wang, Tianyuan; Peddada, Shyamal D; Jaddoe, Vincent W V; Nystad, Wenche; Duijts, Liesbeth; London, Stephanie J (Peer reviewed; Journal article, 2016-02-10)Folate is vital for fetal development. Periconceptional folic acid supplementation and food fortification are recommended to prevent neural tube defects. Mechanisms whereby periconceptional folate influences normal development ... -
Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study
Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S.; Bønaa, Kaare Harald; Nygård, Ottar (Peer reviewed; Journal article, 2017-10)Background: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon‐γ‐mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the ... -
The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK)
Zuo, Hui; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Midttun, Øivind; Meyer, Klaus; Ulvik, Arve (Peer reviewed; Journal article, 2018-01)Background: Vitamin B-6 homeostasis is altered during inflammation and immune activation. It is unknown whether altered vitamin B-6 homeostasis is associated with the risk of stroke. Objective: We investigated the relation ... -
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality. The Hordaland Health Study
Zuo, Hui; Ueland, Per Magne; Ulvik, Arve; Eussen, Simone; Vollset, Stein Emil; Nygård, Ottar; Midttun, Øivind; Theofylaktopoulou, Despoina; Meyer, Klaus; Tell, Grethe Seppola (Peer reviewed; Journal article, 2016)We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause ... -
Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ... -
Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Nitter, Mathilde Hjelle; Norgård, Benedicte Wentzel; De Vogel, Stefan; Eussen, Simone; Meyer, Klaus; Ulvik, Arve; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Bjørge, Tone; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Racine, Antoine; Cottet, Vanessa; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Bamia, Christina; Naska, Androniki; Grioni, Sara; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Van Kranen, Henk J.; Peeters, Petra H. M.; Weiderpass, Elisabete; Dorronsoro, Miren; Jakszyn, Paula; Sánchez, María-José; Argüelles, Marcial Vicente; Huerta, José-Maria; Barricarte, Aurelio; Johansson, Matthias; Ljuslinder, Ingrid; Khaw, Kay Tee; Wareham, Nicholas J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Gunter, Mark J.; Riboli, Élio B. (Peer reviewed; Journal article, 2014-08)Background Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as ... -
The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A
Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga; Nygård, Ottar (Peer reviewed; Journal article, 2018)Background. Plasma total homocysteine (tHcy) has been implicated in the development of cardiovascular disease, but the mechanisms remain unclear. Vitamin A (Vit-A) is involved in homocysteine metabolism and we therefore ...