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Bergen Open Research Archive

Browsing Department of Clinical Medicine by Issue Date

Bergen Open Research Archive

Browsing Department of Clinical Medicine by Issue Date

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  • Tveitnes, Dag (Doctoral thesis, The University of Bergen, 2012-06-08)
    Background: Lyme borreliosis (LB) caused by the bacteria Borrelia burgdorferi sensu lato (Bbsl) is the most common tick transmitted infection in Europe. LB is a multi systemic infection that develops when the bacteria ...
  • Johansson, Stefan; Irgens, Henrik; Chudasama, Kishan K.; Molnes, Janne; Aerts, Jan; Knappskog, Per; Njølstad, Pål Rasmus; Roque, Francisco S.; Jonassen, Inge; Molven, Anders (Peer reviewed; Journal article, Public Library of Science, 2012-05-25)
    Context: Genetic testing for monogenic diabetes is important for patient care. Given the extensive genetic and clinical heterogeneity of diabetes, exome sequencing might provide additional diagnostic potential when ...
  • Maniaol, Angelina H.; Elsais, Ahmed; Lorentzen, Åslaug R.; Owe, Jone F.; Viken, Marte K.; Gilhus, Nils Erik (Peer reviewed; Journal article, Public Library of Science, 2012-05-09)
    Background: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including ...
  • Trovik, Jone (Doctoral thesis, The University of Bergen, 2012-05-04)
    Background: Although endometrial cancer in general has a good prognosis, 15-20% recurs. Surgery is the main treatment with lymph node sampling increasingly advocated as compulsory for adequate staging. In metastatic ...
  • Oveland, Nils Petter; Sloth, Erik; Andersen, Gratien; Lossius, Hans Morten (Journal article; Peer reviewed, Wiley-Blackwell, 2012-05)
    Objectives: Ultrasound (US) is a sensitive diagnostic tool for detecting pneumothorax (PTX), but methods are needed to optimally teach this technique outside of direct patient care. In training and research settings, ...
  • Håvik, Bjarte; Fernandes, Carla P. D.; Christoforou, Andrea; Ersland, Kari Merete; Giddaluru, Sudheer; Cichon, Sven; Steen, Vidar Martin; Hellard, Stéphanie Le; Johansson, Stefan; Bramham, Clive R.; Haavik, Jan (Peer reviewed; Journal article, Public Library of Science, 2012-04-23)
    Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. ...
  • Skrede, Silje (Doctoral thesis, The University of Bergen, 2012-04-20)
    Antipsychotic agents represent efficient therapy for serious psychiatric disorders, particularly schizophrenia, but also bipolar disorder, and are used by millions of patients worldwide. Metabolic adverse effects of ...
  • Baghestan, Elham (Doctoral thesis, The University of Bergen, 2012-03-16)
    Aims: Obstetric anal sphincter injuries (OASIS) are serious complications of vaginal childbirth and may result in severe consequences such as dyspareunia, anal- and urinary incontinence. In Norway and other Scandinavian ...
  • Yndestad, Arne; Finsen, Alexandra Vanessa; Ueland, Thor; Husberg, Cathrine; Dahl, Christen P.; Dickstein, Kenneth (Peer reviewed; Journal article, Public Library of Science, 2012-03-12)
    Background: CCL19 and CCL21, acting through CCR7, are termed homeostatic chemokines. Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that ...
  • Ersland, Kari Merete; Christoforou, Andrea; Stansberg, Christine; Espeseth, Thomas; Mattheisen, Manuel; Mattingsdal, Morten; Hardarson, Gudmundur A.; Hansen, Thomas; Fernandes, Carla P. D.; Giddaluru, Sudheer; Breuer, Rene´; Strohmaier, Jana; Djurovic, Srdjan; Nöthen, Markus M.; Rietschel, Marcella; Lundervold, Astri Johansen; Werge, Thomas; Cichon, Sven; Andreassen, Ole A.; Reinvang, Ivar; Steen, Vidar Martin; Le Hellard, Stephanie (Peer reviewed; Journal article, Public Library of Science, 2012-02-22)
    Background: Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive ...
  • Zhuang, Joanna; Jones, Allison; Lee, Shih-Han; Ng, Esther; Fiegl, Heidi; Zikan, Michal; Cibula, David; Sargent, Alexandra; Salvesen, Helga B.; Jacobs, Ian J.; Kitchener, Henry C.; Teschendorff, Andrew E.; Widschwendter, Martin (Peer reviewed; Journal article, Public Library of Science, 2012-02-09)
    Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical ...
  • Sandhaug, Maria (Doctoral thesis, The University of Bergen, 2012-02-03)
    Objectives: The objectives of the thesis were to describe the functional level (papers I and II) and self awareness of functional deficits (paper III) after moderate and severe Traumatic Brain Injury (TBI), and to ...
  • Frøisland, Dag H.; Markestad, Trond; Wentzel-Larsen, Tore; Skrivarhaug, Torild; Dahl-Jørgensen, Knut; Graue, Marit (Peer reviewed; Journal article, BioMed Central, 2012-02-02)
    Background: International guidelines on type 1 diabetes advocate routine screening of health-related quality of life (HRQOL). DISABKIDS questionnaires are the first instruments developed across cultures and nations to ...
  • Sollid, Stephen J. M.; Rimstad, Rune; Rehn, Marius; Nakstad, Anders R.; Tomlinson, Ann-Elin (Peer reviewed; Journal article, BioMed Central, 2012-01-26)
    Background: On July 22, 2011, a single perpetrator killed 77 people in a car bomb attack and a shooting spree incident in Norway. This article describes the emergency medical service (EMS) response elicited by the two ...
  • Thomassen, Øyvind (Doctoral thesis, The University of Bergen, 2012-01-19)
    Background Adverse events are documented to affect more than one in 25 hospital patients. Medical mishaps and errors are rarely the result of incompetence, poor motivation or negligence but challenges on social and ...
  • Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga B. (Peer reviewed; Journal article, Cancer Research UK and Nature Publishing Group, 2012)
    BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat ...
  • Totland, Cecilie (Doctoral thesis, The University of Bergen, 2011-12-20)
    The mechanisms behind anti-Yo mediated paraneoplastic cerebellar degeneration is still not understood, and very little is known about the function of CDR2. In our studies we have tried to elucidate the properties of Yo ...
  • Dramsdahl, Margaretha (Doctoral thesis, The University of Bergen, 2011-12-09)
    Objective: Divergent brain lateralization and dysfunctional attention and cognitive control may be part of the pathophysiology of ADHD, with the corpus callosum (CC) and the anterior cortex cinguli (ACC) as important ...
  • Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin von; Haavik, Jan; Hugdahl, Kenneth; Specht, Karsten (Peer reviewed; Journal article, Frontiers research foundation, 2011-11-23)
    Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the ...
  • Kilpeläinen, Tuomas O.; Qi, Lu; Brage, Soren; Sharp, Stephen J.; Sonestedt, Emily; Demerath, Ellen; Johansson, Stefan; Njølstad, Pål Rasmus (Peer reviewed; Journal article, Public Library of Science, 2011-11-01)
    Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies ...

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