• Change in paternity, risk of placental abruption and confounding by birth interval: A population-based prospective cohort study in Norway, 1967-2009 

      Ananth, Cande V.; Skjaerven, Rolv; Klungsøyr, Kari (Peer reviewed; Journal article, 2015-02-10)
      Objectives: We examined abruption risk in relation to change in paternity, and evaluated if birth interval confounds this association. Setting: Population-based study of singleton births in Norway between 1967 and 2009. ...
    • Clarity and consistency in stillbirth reporting in Europe: why is it so hard to get this right? 

      Gissler, Mika; Durox, Mélanie; Smith, Lucy; Blondel, Béatrice; Broeders, Lisa; Hindori-Mohangoo, Ashna D.; Kearns, Karen; Kolarova, Rumyana; Loghi, Marzia; Rodin, Urelija; Szamotulska, Katarzyna; Velebil, Petr; Zurriaga, Oscar; Zeitlin, Jennifer; Klungsøyr, Kari (Journal article; Peer reviewed, 2022)
      Background Stillbirth is a major public health problem, but measurement remains a challenge even in high-income countries. We compared routine stillbirth statistics in Europe reported by Eurostat with data from the ...
    • Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: A population-based cross-sectional study 

      Chen, Qi; Hartman, Catharina A; Haavik, Jan; Harro, Jaanus; Klungsøyr, Kari; Hegvik, Tor-Arne; Wanders, Rob; Ottosen, Cæcilie; Dalsgaard, Søren; Faraone, Stephen V.; Larsson, Henrik (Peer reviewed; Journal article, 2018-09-26)
      Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with other psychiatric conditions in adults. Yet, less is known about its relationship with common metabolic disorders and how sex and ageing affect the ...
    • Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations 

      Cohen, Jacqueline Mallory; Alvestad, Silje; Cesta, Carolyn E.; Bjørk, Marte-Helene; Leinonen, Maarit; Nørgaard, Mette; Einarsdóttir, Kristjana; Engeland, Anders; Gissler, Mika; Karlstad, Øystein; Klungsøyr, Kari; Odsbu, Ingvild; Reutfors, Johan; Selmer, Randi Marie; Tomson, Torbjörn; Ulrichsen, Sinna Pilgaard; Zoega, Helga; Furu, Kari (Journal article; Peer reviewed, 2022)
      Objective: This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype. ...
    • Congenital clubfoot in Europe: A population-based study 

      Wang, Hao; Barisic, Ingeborg; Loane, Maria; Addor, Marie-Claude; Bailey, Linda M.; Gatt, Miriam; Klungsøyr, Kari; Mokoroa, Olatz; Nelen, Vera; Neville, Amanda J.; O'Mahony, Mary; Pierini, Anna; Rissmann, Anke; Verellen-Dumoulin, Christine; de Walle, Hermien E.K.; Wiesel, Awi; Wisniewska, Katarzyna; de Jong van den Berg, Lolkje T.W.; Dolk, Helen; Khoshnood, Babak; Garne, Ester (Peer reviewed; Journal article, 2019)
      We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major ...
    • COVID-19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries 

      Engjom, Hilde Marie; Aabakke, Anna J. M.; Klungsøyr, Kari; Svanvik, Teresia; Äyräs, Outi; Jonasdottir, Eva; Thurn, Lars; Jones, Elin; Pettersson, Karin; Nyfløt, Lill Trine; Al-Zirqi, Iqbal Ahmad Abdelwahab; Vangen, Siri; Juliusson, Pétur Benedikt; Källén, Karin; Gissler, Mika; Krebs, Lone (Journal article; Peer reviewed, 2021)
      Introduction Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. Material and ...
    • Do Genetic Variants Modify the Effect of Smoking on Risk of Preeclampsia in Pregnancy? 

      Bauer, Anna E.; Avery, Christy L.; Shi, Min; Weinberg, Clarice R.; Olshan, Andrew F.; Harmon, Quaker E.; Luo, Jingchun; Yang, Jenny; Manuck, Tracy; Wu, Michael C.; Klungsøyr, Kari; Trogstad, Lill; Magnus, Per Minor; Engel, Stephanie M. (Journal article; Peer reviewed, 2021)
      Objective: Maternal smoking is associated with as much as a 50% reduced risk of preeclampsia, despite increasing risk of other poor pregnancy outcomes that often co-occur with preeclampsia, such as preterm birth and fetal ...
    • Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population? 

      Xie, Tian; Schweren, Lizanne J.S.; Larsson, Henrik; Li, Lin; Rietz, Ebba Du; Haavik, Jan; Kvalvik, Liv Grimstvedt; Solberg, Berit Skretting; Klungsøyr, Kari; Snieder, Harold; Hartman, Catharina A. (Journal article; Peer reviewed, 2023-03-27)
      The present study investigated whether an unhealthy diet and other lifestyle behaviors may modify the genetic susceptibility to impulsivity. A total of 33,047 participants (mean age = 42.1 years, 59.8% females) from the ...
    • Does caesarean delivery in the first pregnancy increase the risk for adverse outcome in the second? A registry-based cohort study on first and second singleton births in Norway 

      Bjellmo, Solveig; Andersen, Guro Lillemoen; Hjelle, Sissel; Klungsøyr, Kari; Krebs, Lone; Lydersen, Stian; Romundstad, Pål Richard; Vik, Torstein (Journal article; Peer reviewed, 2020)
      Objective To explore if newborns in the second pregnancy following a previous caesarean delivery (CD) have higher risk of perinatal mortality or cerebral palsy than newborns in pregnancies following a previous vaginal ...
    • Elective cesarean section or not? Maternal age and risk of adverse outcomes at term: a population-based registry study of low-risk primiparous women 

      Herstad, Lina; Klungsøyr, Kari; Skjaerven, Rolv; Tanbo, Tom Gunnar; Forsen, Lisa; Åbyholm, Thomas; Vangen, Siri (Peer reviewed; Journal article, 2016-08-17)
      Background Maternal age at delivery and cesarean section rates are increasing. In older women, the decision on delivery mode may be influenced by a reported increased risk of surgical interventions during labor and ...
    • Epidemiology of congenital cerebral anomalies in Europe: a multicentre, population-based EUROCAT study 

      Morris, Joan K.; Wellesley, Diana G.; Barisic, Ingeborg; Addor, Marie-Claude; Bergman, Jorieke E. H.; Braz, Paula; Cavero-Carbonell, Clara; Draper, Elizabeth S.; Gatt, Miriam; Haeusler, Martin; Klungsøyr, Kari; Kurinczuk, Jennifer J.; Lelong, Natalie; Luyt, Karen; Lynch, Catherine; O'Mahony, Mary T.; Mokoroa, Olatz; Nelen, Vera; Neville, Amanda J.; Pierini, Anna; Randrianaivo, Hanitra; Rankin, Judith; Rissmann, Anke; Rouget, Florence; Schaub, Bruno; Tucker, David F.; Verellen-Dumoulin, Christine; Wiesel, Awi; Zymak-Zakutnia, Natalia; Lanzoni, Monica; Garne, Ester (Peer reviewed; Journal article, 2019)
      Objectives: To describe the epidemiology and geographical differences in prevalence of congenital cerebral anomalies in Europe. Design and setting: Congenital cerebral anomalies (International Classification of Diseases, ...
    • Epidemiology of Dandy-Walker malformation in Europe: A EUROCAT population-based registry study 

      Santoro, Michele; Coi, Alessio; Barišić, Ingeborg; Garne, Ester; Addor, Marie-Claude; Bergman, Jorieke E.H.; Bianchi, Fabrizio; Boban, Ljubica; Braz, Paula; Cavero-Carbonell, Clara; Gatt, Miriam; Haeusler, Martin; Kinsner-Ovaskainen, Agnieszka; Klungsøyr, Kari; Kurinczuk, Jennifer J.; Lelong, Nathalie; Luyt, Karen; Materna-Kiryluk, Anna; Mokoroa, Olatz; Mullaney, Carmel; Nelen, Vera; Neville, Amanda Julie; O'Mahony, Mary T.; Perthus, Isabelle; Randrianaivo, Hanitra; Rankin, Judith; Rissmann, Anke; Rouget, Florence; Schaub, Bruno; Tucker, David; Wellesley, Diana; Yevtushok, Lyubov; Pierini, Anna (Peer reviewed; Journal article, 2019)
      Background: Dandy-Walker (DW) malformation is a rare and severe congenital anomaly of the posterior fossa affecting the development of the cerebellum and the fourth ventricle. Objective: The aim of this study was to ...
    • Epidemiology of limb reduction defects as registered in the Medical Birth Registry of Norway, 1970-2016: Population based study 

      Klungsøyr, Kari; Nordtveit, Tone Irene; Kaastad, Trine Sand; Solberg, Sigrun; Sletten, Ida Neergård; Vik, Anne-Karin (Peer reviewed; Journal article, 2019-07-17)
      Background: Following the Thalidomide disaster, the Medical Birth Registry of Norway (MBRN) was established in 1967, with epidemiological surveillance of congenital anomalies as one main aim. Limb reduction defects (LRD) ...
    • Epidemiology of Pierre-Robin sequence in Europe: A population-based EUROCAT study 

      Santoro, Michele; Coi, Alessio; Barišić, Ingeborg; Pierini, Anna; Addor, Marie-Claude; Baldacci, Silvia; Ballardini, Elisa; Boban, Ljubica; Braz, Paula; Cavero-Carbonell, Clara; de Walle, Hermien E.K.; Draper, Elizabeth S.; Gatt, Miriam; Haeusler, Martin; Klungsøyr, Kari; Kurinczuk, Jennifer J.; Materna-Kiryluk, Anna; Lanzoni, Monica; Lelong, Nathalie; Luyt, Karen; Mokoroa, Olatz; Mullaney, Carmel; Nelen, Vera; O'Mahony, Mary T.; Perthus, Isabelle; Randrianaivo, Hanitra; Rankin, Judith; Rissmann, Anke; Rouget, Florence; Schaub, Bruno; Tucker, David; Wellesley, Diana; Zymak-Zakutnia, Nataliia; Garne, Ester (Journal article; Peer reviewed, 2021)
      Background Pierre Robin sequence (PRS) is a rare congenital anomaly. Respiratory disorders and feeding difficulties represent the main burden. Objective The aim of this study was to investigate the epidemiology of PRS ...
    • Ethics and legal requirements for data linkage in 14 European countries for children with congenital anomalies 

      Claridge, Hugh; Tan, Joachim; Loane, Maria; Garne, Ester; Barisic, Ingeborg; Cavero-Carbonell, Clara; Dias, Carlos; Gatt, Miriam; Jordan, Susan; Khoshnood, Babak; Kiuru-Kuhlefelt, Sonja; Klungsøyr, Kari; Mokoroa Carollo, Olatz; Nelen, Vera; Neville, Amanda J.; Pierini, Anna; Randrianaivo, Hanitra; Rissmann, Anke; Tucker, David; De Walle, Hermien; Wertelecki, Wladimir; Morris, Joan K. (Journal article; Peer reviewed, 2023)
      Introduction: Linking healthcare data sets can create valuable resources for research, particularly when investigating rare exposures or outcomes. However, across Europe, the permissions processes required to access data ...
    • Familial co-aggregation of attention-deficit/ hyperactivity disorder and autoimmune diseases: a cohort study based on Swedish population-wide registers 

      Hegvik, Tor-Arne; Chen, Qi; Kuja-Halkola, Ralf; Klungsøyr, Kari; Butwicka, Agnieszka; Lichtenstein, Paul; Almqvist, Catarina; Faraone, Stephen V.; Haavik, Jan; Larsson, Henrik (Journal article; Peer reviewed, 2021)
      Background Attention-deficit/hyperactivity disorder (ADHD) has been associated with several autoimmune diseases (AD), both within individuals and across relatives, implying common underlying genetic or environmental factors ...
    • Gender Differences in Psychiatric Comorbidity: Population-based study of 40,000 Adults with Attention-Deficit Hyperactivity Disorder 

      Solberg, Berit Skretting; Halmøy, Anne; Engeland, Anders; Igland, Jannicke; Haavik, Jan; Klungsøyr, Kari (Peer reviewed; Journal article, 2017-12-21)
      OBJECTIVE: We aimed at determining whether gender modified associations between ADHD and psychiatric comorbidities in adults. METHOD: We identified adults with ADHD by linking Norwegian national registries and compared ...
    • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 

      Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda (Journal article; Peer reviewed, 2020)
      Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ...
    • Gestational diabetes mellitus and interpregnancy weight change: A population-based cohort study 

      Sørbye, Linn Marie; Skjaerven, Rolv; Klungsøyr, Kari; Morken, Nils-Halvdan (Peer reviewed; Journal article, 2017-08-01)
      Background: Being overweight is an important risk factor for Gestational Diabetes Mellitus (GDM), but the underlying mechanisms are not understood. Weight change between pregnancies has been suggested to be an independent ...
    • Healthcare databases in Europe for studying medicine use and safety during pregnancy 

      Charlton, Rachel A.; Neville, Amanda J.; Jordan, Sue; Pierini, Anna; Damase-Michel, Christine; Klungsøyr, Kari; Andersen, Anne-Marie Nybo; Hansen, Anne Vinkel; Gini, Rosa; Bos, Jens H.J.; Puccini, Aurora; Hurault-Delarue, Caroline; Brooks, Caroline J.; De Jong-van den Berg, Lolkje T.V.; de Vries, Corinne S. (Peer reviewed; Journal article, 2014-06)
      Purpose The aim of this study was to describe a number of electronic healthcare databases in Europe in terms of the population covered, the source of the data captured and the availability of data on key variables required ...