Blar i Bergen Open Research Archive på forfatter "Akslen, Lars A."
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Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
Ellingjord-Dale, Merete; Lee, Eunjung; Couto, Elisabeth; Ozhand, Ali; Qureshi, Samera Azeem; Hofvind, Solveig; Van Den Berg, David J.; Akslen, Lars A.; Grotmol, Tom; Ursin, Giske (Peer reviewed; Journal article, 2012-10-27)Introduction: Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy
Nygård, Yngve; Haukaas, Svein A.; Halvorsen, Ole J.; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian (Peer reviewed; Journal article, 2016-07-08)Background: The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ... -
Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity
Biermann, Martin; Kråkenes, Jostein; Brauckhoff, Katrin; Haugland, Hans Kristian; Akslen, Lars A.; Heinecke, A.; Varhaug, Jan Erik; Brauckhoff, Michael (Peer reviewed; Journal article, 2015-03-13)Background: Positron emission tomography (PET) using fluor-18-deoxyglucose (18F-FDG) with or without computed tomography (CT) is generally accepted as the most sensitive imaging modality for diagnosing recurrent differentiated ... -
Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy
Schuster, Cornelia; Akslen, Lars A.; Stokowy, Tomasz; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment ... -
Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
Hugdahl, Emilia Signe; Bachmann, Ingeborg M.; Schuster, Cornelia; Ladstein, Rita Grude; Akslen, Lars A. (Peer reviewed; Journal article, 2019-01-14)Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and ... -
Quantifying tumour vascularity in non-luminal breast cancers
Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2017)Aims: Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ... -
Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups
Askeland, Cecilie; Wik, Elisabeth; Finne, Kenneth; Birkeland, Even; Arnes, Jarle; Collett, Karin; Knutsvik, Gøril; Krüger, Kristi; Davidsen, Benedicte; Aas, Turid; Eide, Geir Egil; Stefansson, Ingunn; Foulkes, William; Akslen, Lars A. (Journal article; Peer reviewed, 2020)Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, ... -
Stathmin Protein Level, a Potential Predictive Marker for Taxane Treatment Response in Endometrial Cancer
Werner, Henrica Maria Johanna; Trovik, Jone; Halle, Mari Kyllesø; Wik, Elisabeth; Akslen, Lars A.; Birkeland, Even; Bredholt, Therese; Tangen, Ingvild Løberg; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-02-25)Stathmin is a prognostic marker in many cancers, including endometrial cancer. Preclinical studies, predominantly in breast cancer, have suggested that stathmin may additionally be a predictive marker for response to ... -
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies
Schmidt, Marjanka K.; Leeuwen, Flora E. van; Wesseling, Jelle; Cheang, Maggie C. U.; Gelmon, Karen; Nielsen, Torsten O.; Blomqvist, Carl; Heikkilä, Päivi; Heikkinen, Tuomas; Broeks, Annegien; Nevanlinna, Heli; Akslen, Lars A.; Bégin, Louis R.; Foulkes, William D.; Couch, Fergus J.; Wang, Xianshu; Cafourek, Vicky; Olson, Janet E.; Baglietto, Laura; Giles, Graham G.; Severi, Gianluca; McLean, Catriona A.; Southey, Melissa C.; Rakha, Emad; Green, Andrew R.; Ellis, Ian O.; Sherman, Mark E.; Lissowska, Jolanta; Anderson, William F.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Provenzano, Elena; Dawson, Sarah-Jane; Dunning, Alison M.; Humphreys, Manjeet; Easton, Douglas F.; García-Closas, Montserrat; Caldas, Carlos; Pharoah, Paul D.; Huntsman, David G.; Blows, Fiona M.; Driver, Kristy E. (Peer reviewed; Journal article, 2010-05-25)Background Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the ... -
Switch in FOXA1 status associates with endometrial cancer progression
Tangen, Ingvild Løberg; Krakstad, Camilla; Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Øyan, Anne Margrete; Kusonmano, Kanthida; Petersen, Kjell; Kalland, Karl-Henning; Akslen, Lars A.; Trovik, Jone; Rodriguez, Antoni Hurtado; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-05-21)Background: The transcription factor Forkhead box A1 (FOXA1) is suggested to be important in hormone dependent cancers, although with little data for endometrial cancer. We investigated expression levels of FOXA1 in primary ... -
Terminal digit preference: a source of measurement error in breast cancer diameter reporting
Tsuruda, Kaitlyn; Hofvind, Solveig; Akslen, Lars A.; Hoff, Solveig Roth; Veierød, Marit Bragelien (Peer reviewed; Journal article, 2019)Objectives: Women diagnosed with breast cancer are offered treatment and therapy based on tumor characteristics, including tumor diameter. There is scarce knowledge whether tumor diameter is accurately reported, or whether ... -
Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas
Bachmann, Ingeborg M.; Ladstein, Rita Grude; Straume, Oddbjørn; Naumov, George N.; Akslen, Lars A. (Peer reviewed; Journal article, 2008-12-05)Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ... -
Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
Hofvind, Solveig; Holen, Åsne Sørlien; Aase, Hildegunn Siv; Houssami, Nehmat; Sebuødegård, Sofie; Moger, Tron Anders; Haldorsen, Ingfrid S.; Akslen, Lars A. (Peer reviewed; Journal article, 2019)Background: Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast ... -
Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
Tischkowitz, Marc; Brunet, Jean-Sébastien; Bégin, Louis R.; Huntsman, David G.; Cheang, Maggie C. U.; Akslen, Lars A.; Nielsen, Torsten O.; Foulkes, William D. (Peer reviewed; Journal article, 2007-07-24)Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical ...