Blar i Bergen Open Research Archive på forfatter "Brun, Johan G"
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Carbamylation of immunoglobulin abrogates activation of the classical complement pathway
Koro, Catalin; Bielecka, Ewa; Dahl-Knudsen, Anders; Enghild, Jan J; Scavenius, Carsten; Brun, Johan G; Binder, Veronika; Hellvard, Annelie; Bergum, Brith; Jonsson, Roland; Potempa, Jan; Blom, Anna M.; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2014-11)Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory ... -
Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome
Karlsen, Marie; Hansen, Torbjørn; Nordal, Hilde Haugedal; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2015-03-19)Introduction: Sjögren’s syndrome (SS) is a rheumatic autoimmune disease characterized by inflammation of exocrine glands. As autoantibodies are present in a majority of patients, B cells have been suggested to play an ... -
Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients
Beyer, Kathrin; Lie, Stein Atle; Kjellevold, Marian; Dahl, Lisbeth; Brun, Johan G; Bolstad, Anne Isine (Peer reviewed; Journal article, 2018-11)Objectives: Marine ω-3 fatty acids (FAs) and Vitamin D (VitD) are reportedly capable of down-regulating inflammation in rheumatoid arthritis (RA) and periodontal disease. This study was undertaken to relate marine FA and ... -
The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
Nordal, Hilde Haugedal; Brun, Johan G; Halse, Anne-Kristine; Jonsson, Roland; Fagerhol, Magne Kristoffer; Hammer, Hilde Berner (Peer reviewed; Journal article, 2014-10-04)Background. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ... -
Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome
Davies, Richard Allan; Sarkar, Irene; Hammenfors, Daniel; Bergum, Brith; Vogelsang, Petra; Solberg, Silje Michelsen; Gavasso, Sonia; Brun, Johan G; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2019-02-21)Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ... -
Temporomandibular joint pain and associated magnetic resonance findings: a retrospective study with a control group
Eriksen, Elisabeth Schilbred; Hellem, Sølve; Skartveit, Liv; Brun, Johan G; Bøe, Olav Egil; Moen, Ketil; Geitung, Jonn Terje (Journal article; Peer reviewed, 2020)Background To better understand and evaluate clinical usefulness of magnetic resonance imaging (MRI) in diagnosis and treatment of temporomandibular disorders (TMD), parameters for the evaluation are useful. Purpose To ...