Blar i Bergen Open Research Archive på forfatter "Xue, Ying"
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Adenoviral Mediated Expression of BMP2 by Bone Marrow Stromal Cells cultured in 3D Copolymer Scaffolds Enhances Bone Formation
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Bruland, Ove; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-01-25)Selection of appropriate osteoinductive growth factors, suitable delivery method and proper supportive scaffold are critical for a successful outcome in bone tissue engineering using bone marrow stromal cells (BMSC). This ... -
Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect
Sharma, Sunita; Xue, Ying; Xing, Zhe; Yassin, Mohammed Ahmed; Sun, Yang; Lorens, James; Finne-Wistrand, Anna; Sapkota, Dipak; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2019-04-11)Apart from osteogenesis, neovascularization of the defect area is an important determinant for successful bone healing. Accordingly, several studies have employed the combined delivery of VEGFA and BMP2 for bone regeneration. ... -
Altered surface hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells
Xing, Zhe; Cai, Jiazheng; Sun, Yang; Cao, Mengnan; Li, Yi; Xue, Ying; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) (or poly(LLA-co-CL)) porous scaffolds are good candidates for use as ... -
Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis
Fujio, Masahito; Xing, Zhe; Al-Sharabi, Niyaz; Xue, Ying; Yamamoto, Akihito; Hibi, Hideharu; Ueda, Minoru; Fristad, Inge; Mustafa, Kamal (Peer reviewed; Journal article, 2015-11-27)Distraction osteogenesis (DO) is a surgical procedure used to correct various skeletal disorders. Improving the technique by reducing the healing time would be of clinical relevance. The aim of this study was to determine ... -
Conditioned medium from human bone marrow stromal cells attenuates initial inflammatory reactions in dental pulp tissue
Al-Sharabi, Niyaz; Mustafa, Manal; Xue, Ying; Ueda, Minoru; Mustafa, Kamal; Fristad, Inge (Peer reviewed; Journal article, 2016-05-04)Aim: To evaluate the effect of MSC-conditioned medium (CM) on the secretion of pro- and anti-inflammatory cytokines from dental pulp cells (hDPC) in vitro, and on the gene expression in vivo after replantation of rat molars. ... -
Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model
Sharma, Sunita; Sapkota, Dipak; Xue, Ying; Rajthala, Saroj; Yassin, Mohammed Ahmed Alamin Yousif; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2018-01-31)Background: In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence ... -
The effect of hydroxyapatite nanocrystals on osseointegration of titanium implants: an in vivo rabbit study
Breding, Karin; Jimbo, Ryo; Hayashi, Mariko; Xue, Ying; Mustafa, Kamal Babikeir Eln; Andersson, Martin (Peer reviewed; Journal article, 2014-01-19)Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they ... -
The effect of resolvin D1 on bone regeneration in a rat calvarial defect model
Jiang, Xiaofeng; Liu, Jing; Li, Si; Qiu, Yingfei; Wang, Xiaoli; He, Xiaoli; Pedersen, Torbjørn Østvik; Mustafa, Kamal Babikeir Elnour; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Peer reviewed, 2022)Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose of this study was to investigate the effect of RvD1 on bone regeneration using ... -
Endochondral Ossification Induced by Cell Transplantation of Endothelial Cells and Bone Marrow Stromal Cells with Copolymer Scaffold Using a Rat Calvarial Defect Model
Xing, Zhe; Jiang, Xiaofeng; Si, Qingzong; Finne-Wistrand, Anna; Liu, Bin; Xue, Ying; Mustafa, Kamal Babikeir Elnour (Journal article; Peer reviewed, 2021)It has been recently reported that, in a rat calvarial defect model, adding endothelial cells (ECs) to a culture of bone marrow stromal cells (BMSCs) significantly enhanced bone formation. The aim of this study is to further ... -
Endothelial cells influence the osteogenic potential of bone marrow stromal cells
Xue, Ying; Xing, Zhe; Hellem, Sølve; Arvidson, Kristina Fyrberg; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2009-11-17)Background: Improved understanding of the interactions between bone cells and endothelial cells involved in osteogenesis should aid the development of new strategies for bone tissue engineering. The aim of the present study ... -
Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs
Pedersen, Torbjørn Østvik; Blois, Anna L; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James B.; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2013-05-17)Introduction: A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic ... -
Impact of a staggered scaffold structure on the mechanical properties and cell response in bone tissue engineering
He, Xiaoli; Zhao, Qian; Zhang, Ningning; Wang, Junbin; Si, Qingzong; Xue, Ying; Xing, Zhe (Journal article; Peer reviewed, 2023)The primary goal of bone tissue engineering is to fabricate scaffolds that can provide a microenvironment similar to that of natural bone. Therefore, various scaffolds have been designed to replicate the bone structure. ... -
Impact of fish protein concentrate on apparent viscosity and physical properties of soy protein concentrate subjected to thermomechanical treatment
Ahmad, Rafiq; Oterhals, Åge; Xue, Ying; Skodvin, Tore; Samuelsen, Tor Andreas (Peer reviewed; Journal article, 2019-04-30)The aim of this research was to investigate the plasticizing and binding effect of fish protein concentrate (FPC) on soy protein concentrate (SPC) with the use of a capillary rheometer with pre-shearing capabilities. A ... -
In vivo host response and degradation of copolymer scaffolds functionalized with nanodiamonds and bone morphogenetic protein 2
Suliman, Salwa; Sun, Yang; Pedersen, Torbjørn Østvik; Xue, Ying; Nickel, Joachim; Waag, Thilo; Finne-Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Costea, Daniela Elena; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2016-03)The aim is to evaluate the effect of modifying poly[(l-lactide)-co-(ε-caprolactone)] scaffolds (PLCL) with nanodiamonds (nDP) or with nDP+physisorbed BMP-2 (nDP+BMP-2) on in vivo host tissue response and degradation. The ... -
Influence of bone marrow stromal cell secreted molecules on pulpal and periodontal healing in replanted immature rat molars
Al-Sharabi, Niyaz; Xue, Ying; Ueda, Minoru; Mustafa, Kamal; Fristad, Inge (Peer reviewed; Journal article, 2015-12-10)Aim. To investigate the effect of paracrine factors secreted from human bone marrow stromal cell (BMSC-CM) on pulpal and periodontal healing following immediate replantation of maxillary rat first molars. Material and ... -
Interactions between endothelial and bone marrow stromal cells of relevance to bone tissue engineering
Xue, Ying (Doctoral thesis, 2011-02-04)Much research effort is being directed towards the development of bone tissue engineering techniques as alternatives to grafts for the treatment of bone defects. A major challenge is that following implantation of the ... -
Label-free impedance flow cytometry for nanotoxicity screening
Ostermann, Melanie; Sauter, Alexander; Xue, Ying; Birkeland, Eivind Salmorin; Schoelermann, Julia; Holst, Bodil; Cimpan, Mihaela Roxana (Peer reviewed; Journal article, 2020)The development of reliable and cost-efficient methods to assess the toxicity of nanomaterials (NMs) is critical for the proper identification of their impact on human health and for ensuring a safe progress of nanotechnology. ... -
Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling
Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-12-20)Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ... -
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation
Pedersen, Torbjørn Østvik; Blois, Anna L; Xue, Ying; Xing, Zhe; Sun, Yang; Finne-Wistrand, Anna; Lorens, James B.; Fristad, Inge; Leknes, Knut N.; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2014-02-17)Introduction: Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a complex regulating ... -
Release and bioactivity of bone morphogenetic protein-2 are affected by scaffold binding techniques in vitro and in vivo
Suliman, Salwa; Xing, Zhe; Wu, X; Xue, Ying; Pedersen, Torbjørn Østvik; Sun, Y; Døskeland, Anne Marie Simonne; Nickel, Joachim; Waag, Thilo; Lygre, Henning; Finne Wistrand, Anna; Steinmüller-Nethl, Doris; Krueger, Anke; Mustafa, Kamal Babikeir Eln (Peer reviewed; Journal article, 2015-01-10)A low dose of 1 μg rhBMP-2 was immobilised by four different functionalising techniques on recently developed poly(l-lactide)-co-(ε-caprolactone) [(poly(LLA-co-CL)] scaffolds. It was either (i) physisorbed on unmodified ...