dc.contributor.author | Bastard, Paul | |
dc.contributor.author | Rosen, Lindsey B. | |
dc.contributor.author | Zhang, Qian | |
dc.contributor.author | Michailidis, Eleftherios | |
dc.contributor.author | Hoffmann, Hans-Heinrich | |
dc.contributor.author | Zhang, Yu | |
dc.contributor.author | Dorgham, Karim | |
dc.contributor.author | Philippot, Quentin | |
dc.contributor.author | Rosain, Jérémie | |
dc.contributor.author | Béziat, Vivien | |
dc.contributor.author | Manry, Jérémy | |
dc.contributor.author | Shaw, Elana | |
dc.contributor.author | Haljasmägi, Liis | |
dc.contributor.author | Peterson, Pärt | |
dc.contributor.author | Lorenzo, Lazaro | |
dc.contributor.author | Bizien, Lucy | |
dc.contributor.author | Trouillet-Assant, Sophie | |
dc.contributor.author | Dobbs, Kerry | |
dc.contributor.author | de Jesus, Adriana Almeida | |
dc.contributor.author | Belot, Alexandre | |
dc.contributor.author | Kallaste, Anne | |
dc.contributor.author | Catherinot, Emilie | |
dc.contributor.author | Tandjaoui-Lambiotte, Yacine | |
dc.contributor.author | Le Pen, Jeremie | |
dc.contributor.author | Kerner, Gaspard | |
dc.contributor.author | Bigio, Benedetta | |
dc.contributor.author | Seeleuthner, Yoann | |
dc.contributor.author | Yang, Rui | |
dc.contributor.author | Bolze, Alexandre | |
dc.contributor.author | Spaan, András N | |
dc.contributor.author | Delmonte, Ottavia M. | |
dc.contributor.author | Abers, Michael S. | |
dc.contributor.author | Aiuti, Alessandro | |
dc.contributor.author | Casari, Giorgio | |
dc.contributor.author | Lampasona, Vito | |
dc.contributor.author | Piemonti, Lorenzo | |
dc.contributor.author | Ciceri, Fabio | |
dc.contributor.author | Bilguvar, Kaya | |
dc.contributor.author | Lifton, Richard P. | |
dc.contributor.author | Vasse, Marc | |
dc.contributor.author | Smadja, David M. | |
dc.contributor.author | Migaud, Mélanie | |
dc.contributor.author | Hadjadj, Jérome | |
dc.contributor.author | Terrier, Benjamin | |
dc.contributor.author | Duffy, Darragh | |
dc.contributor.author | Quintana-Murci, Lluis | |
dc.contributor.author | van de Beek, Diederik | |
dc.contributor.author | Roussel, Lucie | |
dc.contributor.author | Vinh, Donald C. | |
dc.contributor.author | Tangye, Stuart G. | |
dc.contributor.author | Haerynck, Filomeen | |
dc.contributor.author | Dalmau, David | |
dc.contributor.author | Martinez-Picado, Javier | |
dc.contributor.author | Brodin, Petter | |
dc.contributor.author | Nussenzweig, Michel C. | |
dc.contributor.author | Boisson-Dupuis, Stéphanie | |
dc.contributor.author | Rodríguez-Gallego, Carlos | |
dc.contributor.author | Vogt, Guillaume | |
dc.contributor.author | Mogensen, Trine H. | |
dc.contributor.author | Oler, Andrew J. | |
dc.contributor.author | Gu, Jingwen | |
dc.contributor.author | Burbelo, Peter D. | |
dc.contributor.author | Cohen, Jeffrey I. | |
dc.contributor.author | Biondi, Andrea | |
dc.contributor.author | Bettini, Laura Rachele | |
dc.contributor.author | D'Angio, Mariella | |
dc.contributor.author | Bonfanti, Paolo | |
dc.contributor.author | Rossignol, Patrick | |
dc.contributor.author | Mayaux, Julien | |
dc.contributor.author | Rieux-Laucat, Frédéric | |
dc.contributor.author | Husebye, Eystein Sverre | |
dc.contributor.author | Fusco, Francesca | |
dc.contributor.author | Ursini, Matilde Valeria | |
dc.contributor.author | Imberti, Luisa | |
dc.contributor.author | Sottini, Alessandra | |
dc.contributor.author | Paghera, Simone | |
dc.contributor.author | Quiros-Roldan, Eugenia | |
dc.contributor.author | Rossi, Camillo | |
dc.contributor.author | Castagnoli, Riccardo | |
dc.contributor.author | Montagna, Daniela | |
dc.contributor.author | Licari, Amelia | |
dc.contributor.author | Marseglia, Gian Luigi | |
dc.contributor.author | Duval, Xavier | |
dc.contributor.author | Ghosn, Jade | |
dc.contributor.author | Tsang, John S. | |
dc.contributor.author | Goldbach-Mansky, Raphaela | |
dc.contributor.author | Kisand, Kai | |
dc.contributor.author | Lionakis, Michail | |
dc.contributor.author | Puel, Anne | |
dc.contributor.author | Zhang, Shen-Ying | |
dc.contributor.author | Holland, Steven M. | |
dc.contributor.author | Gorochov, Guy | |
dc.contributor.author | Jouanguy, Emmanuelle | |
dc.contributor.author | Rice, Charles M. | |
dc.contributor.author | Cobat, Aurelie | |
dc.contributor.author | Notarangelo, Luigi D. | |
dc.contributor.author | Abel, Laurent | |
dc.contributor.author | Su, Helen C. | |
dc.contributor.author | Casanova, Jean-Laurent | |
dc.date.accessioned | 2021-04-23T07:39:14Z | |
dc.date.available | 2021-04-23T07:39:14Z | |
dc.date.created | 2020-11-13T18:36:48Z | |
dc.date.issued | 2020 | |
dc.Published | Science. 2020, 370:eabd4585 (6515), 1-15. | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.uri | https://hdl.handle.net/11250/2739235 | |
dc.description.abstract | Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | AAAS | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. | en_US |
dc.source.articlenumber | eabd4585 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.doi | 10.1126/science.abd4585 | |
dc.identifier.cristin | 1847904 | |
dc.source.journal | Science | en_US |
dc.source.40 | 370:eabd4585 | |
dc.source.14 | 6515 | |
dc.identifier.citation | Science. 2020, 370, (6515), eabd4585 | en_US |
dc.source.volume | 370 | en_US |
dc.source.issue | 6515 | en_US |