dc.contributor.author | Strand, Kristina | |
dc.contributor.author | Stiglund, Natalie | |
dc.contributor.author | Haugstøyl, Martha Eimstad | |
dc.contributor.author | Kamyab, Seyedeh Zahra | |
dc.contributor.author | Langhelle, Victoria Puntervold | |
dc.contributor.author | Dyer, Laurence | |
dc.contributor.author | Busch, Christian | |
dc.contributor.author | Cornillet, Martin | |
dc.contributor.author | Hjellestad, Iren Drange | |
dc.contributor.author | Nielsen, Hans Jørgen | |
dc.contributor.author | Njølstad, Pål Rasmus | |
dc.contributor.author | Mellgren, Gunnar | |
dc.contributor.author | Björkström, Niklas K. | |
dc.contributor.author | Fernø, Johan | |
dc.date.accessioned | 2022-06-08T09:21:41Z | |
dc.date.available | 2022-06-08T09:21:41Z | |
dc.date.created | 2022-05-13T17:03:59Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1664-2392 | |
dc.identifier.uri | https://hdl.handle.net/11250/2997834 | |
dc.description.abstract | A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis of metabolic diseases, but a detailed characterization of pro- and anti-inflammatory adipose tissue macrophages (ATMs) in human obesity and how they are distributed in visceral- and subcutaneous adipose depots is lacking. In this study, we performed a surface proteome screening of pro- and anti-inflammatory ATMs in both subcutaneous- (SAT) and visceral adipose tissue (VAT) and evaluated their relationship with systemic insulin resistance. From the proteomics screen we found novel surface proteins specific to M1-like- and M2-like macrophages, and we identified depot-specific immunophenotypes in SAT and VAT. Furthermore, we found that insulin resistance, assessed by HOMA-IR, was positively associated with a relative increase in pro-inflammatory M1-like macrophages in both SAT and VAT. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.source.articlenumber | 856530 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3389/fendo.2022.856530 | |
dc.identifier.cristin | 2024514 | |
dc.source.journal | Frontiers in Endocrinology | en_US |
dc.identifier.citation | Frontiers in Endocrinology. 2022, 13, 856530. | en_US |
dc.source.volume | 13 | en_US |