dc.contributor.author | Paul, Elisabeth R. | |
dc.contributor.author | Östman, Lars | |
dc.contributor.author | Heilig, Markus | |
dc.contributor.author | Mayberg, Helen S. | |
dc.contributor.author | Hamilton, Paul | |
dc.date.accessioned | 2024-01-16T12:36:41Z | |
dc.date.available | 2024-01-16T12:36:41Z | |
dc.date.created | 2023-06-02T17:47:50Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | https://hdl.handle.net/11250/3111840 | |
dc.description.abstract | Biological assay and imaging techniques have made visible a great deal of the machinery of mental illness. Over fifty years of investigation of mood disorders using these technologies has identified several biological regularities in these disorders. Here we present a narrative connecting genetic, cytokine, neurotransmitter, and neural-systems-level findings in major depressive disorder (MDD). Specifically, we connect recent genome-wide findings in MDD to metabolic and immunological disturbance in this disorder and then detail links between immunological abnormalities and dopaminergic signaling within cortico-striatal circuitry. Following this, we discuss implications of reduced dopaminergic tone for cortico-striatal signal conduction in MDD. Finally, we specify some of the flaws in the current model and propose ways forward for advancing multilevel formulations of MDD most efficiently. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Towards a multilevel model of major depression: genes, immuno-metabolic function, and cortico-striatal signaling | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.source.articlenumber | 171 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1038/s41398-023-02466-7 | |
dc.identifier.cristin | 2151411 | |
dc.source.journal | Translational Psychiatry | en_US |
dc.identifier.citation | Translational Psychiatry. 2023, 13 (1), 171. | en_US |
dc.source.volume | 13 | en_US |
dc.source.issue | 1 | en_US |