dc.contributor.author | Nes, Magne Solberg | |
dc.contributor.author | Haugen, Mette | |
dc.contributor.author | Haugland, Hans Kristian | |
dc.contributor.author | Gilhus, Nils Erik | |
dc.contributor.author | Vedeler, Christian Alexander | |
dc.date.accessioned | 2024-04-19T13:34:52Z | |
dc.date.available | 2024-04-19T13:34:52Z | |
dc.date.created | 2023-11-07T15:21:21Z | |
dc.date.issued | 2023-10-12 | |
dc.identifier.issn | 1664-2295 | |
dc.identifier.uri | https://hdl.handle.net/11250/3127466 | |
dc.description.abstract | Objectives: Autoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine receptor (AChR)-positive patient with myasthenia gravis who developed limbic encephalitis with antibodies to AMPAR and Lgi1.
Methods: A single-case report with detailed, prospective clinical and biomarker data including serial laboratory testing and histopathology.
Results: A 49-year-old woman was diagnosed with anti-AChR antibody-positive generalized myasthenia gravis in 1983. After 9 months of the removal of thymoma in 1984, she developed influenza-like symptoms and then symptoms of limbic encephalitis. Retrospective analysis of serum showed high concentrations of anti-AMPAR and lower concentrations of anti-Lgi1 antibodies. Cerebral CT was normal, EEG showed bifrontal dysrhythmia, and CSF showed mild pleocytosis. Immuno-histochemical examination of the thymoma confirmed staining for Glur2, a subunit of AMPAR. The patient recovered with mild sequelae, but low levels of anti-AMPAR and anti-Lgi1 antibodies were detectable for over 25 years subsequently.
Discussion: This case confirms earlier reports of AMPAR-associated autoimmune encephalitis co-occurring with thymoma and myasthenia gravis and is unique in its observational length. It shows, moreover, that antibodies to AMPAR and Lgi1 can persist despite clinical recovery. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1 | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2023 the authors | en_US |
dc.source.articlenumber | 1237140 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3389/fneur.2023.1237140 | |
dc.identifier.cristin | 2193431 | |
dc.source.journal | Frontiers in Neurology | en_US |
dc.identifier.citation | Frontiers in Neurology. 2023, 14, 1237140. | en_US |
dc.source.volume | 14 | en_US |