Blar i Department of Biomedicine på utgivelsesdato
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Impact of marine oils in inflammatory bowel disease and psoriatic arthritis. With focus on effects of seal oil and whale oil on joint pain
(Doctoral thesis, 2009-09-25)The Western diet has changed significantly over the last century, e.g. by an increased ratio of omega-6 (n-6) to n-3 polyunsaturated fatty acids (PUFA), particularly due to an increase in the use of vegetable oils like soy ... -
Correlations between measures of executive attention and cortical thickness of left posterior middle frontal gyrus - a dichotic listening study
(Peer reviewed; Journal article, 2009-10-01)Background: The frontal lobe has been associated to a wide range of cognitive control functions and is also vulnerable to degeneration in old age. A recent study by Thomsen and colleagues showed a difference between a young ... -
Preparing for an influenza pandemic: Re-evaluating the use of the whole inactivated virus vaccine formulation. –A comparison of the immune responses after intramuscular or intranasal immunization with an influenza H5N1 whole inactivated virus vaccine in a murine model.
(Master thesis, 2009-10-22)Influenza is a highly contagious respiratory disease which infects millions of people every year around the world. Influenza viruses undergo continuous antigen change and annual vaccination is an effective prophylactic ... -
Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
(Peer reviewed; Journal article, 2009-11-13)Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ... -
An eGFP expressing immunodeficent mouse model with dsRED transfected mammary tumours, and the effect of hyperbaric oxygen treatment
(Master thesis, 2009-11-20)Previous studies have shown significant anti-tumour effects of hyperbaric oxygen (HBO) treatment on chemically induced mammary tumours. Thus, to answer whether HBO has a general anti-tumour effect on mammary tumours, the ... -
Dendritic cells loaded with tumor antigens and a dual immunostimulatory and anti-IL-10 specific siRNA can prime T lymphocytes against leukemic cells
(Peer reviewed; Journal article, 2009-12)Vaccines using dendritic cells (DCs) harboring leukemic antigens to stimulate T cells is a possible treatment of acute myeloid leukemia (AML). Limitations of breaking tolerance to leukemic cells and lack of specific ... -
Monte Carlo vs. Pencil Beam based optimization of stereotactic lung IMRT
(Peer reviewed; Journal article, 2009-12-12)Background: The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT). Materials and methods: ... -
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma
(Peer reviewed; Journal article, 2009-12-17)Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and ... -
A reproducible brain tumour model established from human glioblastoma biopsies
(Peer reviewed; Journal article, 2009-12-29)Background: Establishing clinically relevant animal models of glioblastoma multiforme (GBM) remains a challenge, and many commonly used cell line-based models do not recapitulate the invasive growth patterns of patient ... -
The Arc of synaptic memory
(Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
Regulatory Peptides from Chromogranin A and Secretogranin II
(Peer reviewed; Journal article, 2010)This commentary is focusing on novel aspects on the secreted CgA- and SgII-derived peptides, vasostatin-I (bovine and human CgA1–76, VS-I), WE-14 (CgA316–329), catestatin (bovine CgA344–366, human CgA352–372, Cts) and the ... -
HAMLET interacts with lipid membranes and perturbs their structure and integrity
(Peer reviewed; Journal article, 2010-01-23)Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ... -
Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
(Peer reviewed; Journal article, 2010-02-23)Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on ... -
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
(Peer reviewed; Journal article, 2010-06-01)Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy with ... -
Function and regulation of phenylalanine and tyrosine hydroxylases from human and Caenorhabditis elegans. With focus in evolutionary aspects and development of new therapies
(Doctoral thesis, 2010-06-11)The family of the aromatic amino acid hydroxylases (AAAH) is well studied in mammals. It includes four members, i.e. phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and 2). ... -
UCP1 induction during recruitment of Brown Adipocytes in White Adipose tissue is dependent on Cyclooxygenase activity
(Peer reviewed; Journal article, 2010-06-30)Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis. Methodology/Principal Findings Here we report that cyclooxygenase (COX) activity and ... -
Interstitial fluid: the overlooked component of the tumor microenvironment?
(Peer reviewed; Journal article, 2010-07-23)Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the ... -
The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity
(Peer reviewed; Journal article, 2010-08-06)Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ... -
Filamin A binds to CCR2B and regulates its internalization
(Peer reviewed; Journal article, 2010-08-17)The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory ... -
Translational regulation in the adult brain: mediated by BDNF signalling, stress, and chronic antidepressant treatment
(Doctoral thesis, 2010-09-01)One of the most amazing features of the brain is its plasticity. This is a fundamental process by which the brain acquires information and makes the appropriate adaptive changes, a process that makes us able to think, feel, ...