Department of Biomedicine: Nye registreringer
Viser treff 21-40 av 737
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Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma
(Journal article; Peer reviewed, 2023)Aims PSMD family members, as important components of the 26S proteasome, are well known to be involved in protein degradation. However, their role in glioblastoma (GBM) has not been rigorously investigated. We aimed to ... -
Task-based functional connectivity reveals aberrance with the salience network during emotional interference in late-life depression
(Journal article; Peer reviewed, 2023)Objectives Late-life depression (LLD) is a common and debilitating disorder. Previously, resting-state studies have revealed abnormal functional connectivity (FC) of brain networks in LLD. Since LLD is associated with ... -
Risk factors of suicidal spectrum behaviors in adults and adolescents with attention-deficit / hyperactivity disorder – a systematic review
(Journal article; Peer reviewed, 2023-08-21)Introduction: Adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of suicidal spectrum behaviors (SSBs). However, there is limited knowledge about risk factors triggering SSBs ... -
Oral microbiome in a general population - The influence of sample site and sampling method
(Master thesis, 2023-08-02)Oral microbiome profiles reflect the sample types and methodology used to investigate them. The composition of microbes in the oral cavity is site specific. It can also vary due to differences in how a site is sampled. ... -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ... -
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
(Journal article; Peer reviewed, 2023)Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with ... -
Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression
(Master thesis, 2023-06-01)Stiffness regulation within the tumour microenvironment plays a pivotal role in tumorigenesis. In this context, integrin α11β1 is a collagen receptor expressed on cancer-associated fibroblasts (CAFs) involved in matrix ... -
Glioblastom hos voksne
(Journal article; Peer reviewed, 2023)Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i ... -
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
(Journal article; Peer reviewed, 2023-05-12)Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding ... -
3D Modelling of Brain Metastasis Microenvironment for Evaluation of Tumour-Stromal Interactions
(Master thesis, 2023-06-01)Brain metastases (BM) occur when cancer cells from the primary location spread to the brain through the bloodstream. BM affects approximately 20-40 % of cancer patients, with the majority originating from lung, breast, and ... -
Investigation of the apoptotic pathway in glioblastoma in the context of suicide gene therapy
(Master thesis, 2023-06-01)Glioblastoma is a highly malignant, aggressive and most common primary brain tumor in adults. Tremendous research efforts have been conducted in the field of GBM treatment discovery and succcess has only been achieved at ... -
LPS quantification of oral samples from the RHINESSA study population
(Master thesis, 2023-06-01)The human immune system defends the body against threats through a complex network of organs, cells, and proteins. It has two subsystems: the innate immune system provides immediate defense, while the adaptive immune system ... -
The in vitro effect of cytokine autoantibodies on Th17-differentiation and function
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Expression, Purification, and Small Molecule Binding to Cysteine Sulfinic Acid Decarboxylase
(Master thesis, 2023-06-01)Cysteine Sulfinic acid decarboxylase (CSAD) is a PLP-dependent enzyme involved in the biosynthesis of taurine. It converts cysteine sulfinic acid (CSA) into hypotaurine. Hypotaurine is later oxidized into taurine, one of ... -
The CEL VNTR in pancreatic disease: Effects of cysteine residues in pathogenic carboxyl ester lipase variants
(Master thesis, 2023-06-01)Carboxyl ester lipase (CEL) is a digestive enzyme mainly expressed in the acinar cells of the pancreas. CEL hydrolyses dietary fat, cholesteryl esters and fat-soluble vitamins. The protein is structurally divided into two ... -
High-dimensional Characterisation of rare cerebrospinal fluid cells in relapsing remitting multiple sclerosis patients
(Master thesis, 2023-06-01)Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) and is the leading cause of neurological disability in young adults in North America and Europe, affecting ... -
Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants
(Journal article; Peer reviewed, 2023)Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health. Few previous studies have ... -
Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview
(Journal article; Peer reviewed, 2023)Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) ...